ID   CRYGS_CYPCA             Reviewed;         174 AA.
AC   P10112;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Gamma-crystallin S;
DE   AltName: Full=Beta-crystallin S;
DE   AltName: Full=Gamma-S-crystallin;
GN   Name=crygs;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=3307924; DOI=10.1016/0167-4781(87)90098-4;
RA   Chang T., Chang W.-C.;
RT   "Cloning and sequencing of a carp beta s-crystallin cDNA.";
RL   Biochim. Biophys. Acta 910:89-92(1987).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; M26834; AAA49206.1; -; mRNA.
DR   PIR; S07146; S07146.
DR   RefSeq; XP_018950186.1; XM_019094641.1.
DR   AlphaFoldDB; P10112; -.
DR   SMR; P10112; -.
DR   Ensembl; ENSCCRT00000089093; ENSCCRP00000082105; ENSCCRG00000044635.
DR   Ensembl; ENSCCRT00010022094; ENSCCRP00010020178; ENSCCRG00010008758.
DR   Ensembl; ENSCCRT00015121669; ENSCCRP00015117933; ENSCCRG00015046516.
DR   Ensembl; ENSCCRT00020047360; ENSCCRP00020043412; ENSCCRG00020019296.
DR   GeneID; 109079486; -.
DR   KEGG; ccar:109079486; -.
DR   GeneTree; ENSGT00940000160342; -.
DR   OrthoDB; 1225331at2759; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..174
FT                   /note="Gamma-crystallin S"
FT                   /id="PRO_0000057567"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          90..130
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          131..173
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..89
FT                   /note="Connecting peptide"
SQ   SEQUENCE   174 AA;  20829 MW;  9C9618DC18A81877 CRC64;
     MGRIIFYEDK NFQGRRYECD SDCSDFHAFL NRCNSIRVES GAWVIYERPN FMGYQYVLTR
     GEYPDYQRWM GLNDRLCSCK MIHFVSGSEY KIQLYDKGDF TGQVYESTED CPSVVDRFRT
     REVHSCKVLD GIWIFYEHPN YRGRQYLLEK GEYRKPVDWG AVCPTVQSFK RLME