ID   CRYGS_MACFL             Reviewed;         178 AA.
AC   Q5EF38;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Gamma-crystallin S;
DE   AltName: Full=Beta-crystallin S;
DE   AltName: Full=Gamma-S-crystallin;
GN   Name=CRYGS;
OS   Macropus fuliginosus (Western gray kangaroo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=15853812; DOI=10.1111/j.1742-4658.2005.04655.x;
RA   Wistow G., Wyatt K., David L., Gao C., Bateman O., Bernstein S.,
RA   Tomarev S., Segovia L., Slingsby C., Vihtelic T.;
RT   "Gamma-N-crystallin and the evolution of the betagamma-crystallin
RT   superfamily in vertebrates.";
RL   FEBS J. 272:2276-2291(2005).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; AY898646; AAW82718.1; -; mRNA.
DR   AlphaFoldDB; Q5EF38; -.
DR   SMR; Q5EF38; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P22914"
FT   CHAIN           2..178
FT                   /note="Gamma-crystallin S"
FT                   /id="PRO_0000289606"
FT   DOMAIN          6..44
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          45..87
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          94..134
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          135..177
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          2..5
FT                   /note="N-terminal arm"
FT   REGION          88..93
FT                   /note="Connecting peptide"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P22914"
SQ   SEQUENCE   178 AA;  20964 MW;  4AEEE1E3D5C56835 CRC64;
     MSKSVAKITF YDDKNFQGHH YECDSDCPDF HTYLSCCNSI RVTGGAWVVY ERPNFSGNMY
     ILTQGDYPDY HHWRGLNDRL SSCKVIHLSS GGQYKLQIFE RGDFSGQMYE TTEDCPSVME
     QFHIREIQSC KVLDGVWVFY EQPNYYGRQY FLDKKEYRKP VDWGSPCSAV QSFRRIME