CRYGS_MOUSE
ID CRYGS_MOUSE Reviewed; 178 AA.
AC O35486;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Gamma-crystallin S;
DE AltName: Full=Beta-crystallin S;
DE AltName: Full=Gamma-S-crystallin;
GN Name=Crygs;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/Sv, and FVB/N; TISSUE=Lens;
RX PubMed=9565648;
RA Sinha D., Esumi N., Jaworski C., Kozak C., Pierce E., Wistow G.;
RT "Cloning and mapping the mouse Crygs gene and non-lens expression of
RT [gamma]S-crystallin.";
RL Mol. Vis. 4:8-8(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; AF032995; AAC53579.1; -; mRNA.
DR EMBL; AF055703; AAC40120.1; -; Genomic_DNA.
DR EMBL; AF055702; AAC40120.1; JOINED; Genomic_DNA.
DR EMBL; BC056452; AAH56452.1; -; mRNA.
DR CCDS; CCDS28069.1; -.
DR RefSeq; NP_034097.1; NM_009967.2.
DR PDB; 1ZWM; NMR; -; A=2-178.
DR PDB; 1ZWO; NMR; -; A=2-178.
DR PDB; 2A5M; NMR; -; A=2-178.
DR PDB; 6MYG; X-ray; 2.92 A; A/B/C/D=1-178.
DR PDB; 7RJ0; X-ray; 2.92 A; A/B/C/D=2-178.
DR PDBsum; 1ZWM; -.
DR PDBsum; 1ZWO; -.
DR PDBsum; 2A5M; -.
DR PDBsum; 6MYG; -.
DR PDBsum; 7RJ0; -.
DR AlphaFoldDB; O35486; -.
DR SMR; O35486; -.
DR BioGRID; 198922; 1.
DR STRING; 10090.ENSMUSP00000043588; -.
DR PhosphoSitePlus; O35486; -.
DR PaxDb; O35486; -.
DR PRIDE; O35486; -.
DR ProteomicsDB; 285305; -.
DR Antibodypedia; 33848; 206 antibodies from 23 providers.
DR DNASU; 12970; -.
DR Ensembl; ENSMUST00000040592; ENSMUSP00000043588; ENSMUSG00000033501.
DR GeneID; 12970; -.
DR KEGG; mmu:12970; -.
DR UCSC; uc007ysj.2; mouse.
DR CTD; 1427; -.
DR MGI; MGI:1298216; Crygs.
DR VEuPathDB; HostDB:ENSMUSG00000033501; -.
DR eggNOG; ENOG502QQAM; Eukaryota.
DR GeneTree; ENSGT00940000160342; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; O35486; -.
DR OMA; PVEWGAV; -.
DR OrthoDB; 1225331at2759; -.
DR PhylomeDB; O35486; -.
DR BioGRID-ORCS; 12970; 2 hits in 74 CRISPR screens.
DR EvolutionaryTrace; O35486; -.
DR PRO; PR:O35486; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; O35486; protein.
DR Bgee; ENSMUSG00000033501; Expressed in epithelium of lens and 30 other tissues.
DR ExpressionAtlas; O35486; baseline and differential.
DR Genevisible; O35486; MM.
DR GO; GO:0005212; F:structural constituent of eye lens; IMP:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Eye lens protein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P22914"
FT CHAIN 2..178
FT /note="Gamma-crystallin S"
FT /id="PRO_0000057566"
FT DOMAIN 6..44
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 45..87
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 94..134
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 135..177
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 2..5
FT /note="N-terminal arm"
FT REGION 88..93
FT /note="Connecting peptide"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P22914"
FT STRAND 7..13
FT /evidence="ECO:0007829|PDB:6MYG"
FT TURN 14..16
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 17..25
FT /evidence="ECO:0007829|PDB:6MYG"
FT TURN 31..33
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 39..55
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 64..67
FT /evidence="ECO:0007829|PDB:6MYG"
FT HELIX 70..73
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 82..86
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 95..102
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 106..113
FT /evidence="ECO:0007829|PDB:6MYG"
FT HELIX 118..122
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 129..135
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 137..142
FT /evidence="ECO:0007829|PDB:6MYG"
FT TURN 143..145
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 146..152
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 154..159
FT /evidence="ECO:0007829|PDB:6MYG"
FT HELIX 160..163
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 166..168
FT /evidence="ECO:0007829|PDB:6MYG"
FT STRAND 172..175
FT /evidence="ECO:0007829|PDB:6MYG"
SQ SEQUENCE 178 AA; 20850 MW; 40AD1B4835A87C4B CRC64;
MSKTGGKISF YEDRNFQGRR YDCDCDCADF RSYLSRCNSI RVEGGTWAVY ERPNFSGHMY
ILPQGEYPEY QRWMGLNDRL GSCRAVHLSS GGQAKIQVFE KGDFNGQMYE TTEDCPSIME
QFHLREIHSC KVVEGTWIFY ELPNYRGRQY LLDKKEYRKP VDWGAASPAI QSFRRIVE
