ID   CRYGS_RABIT             Reviewed;         179 AA.
AC   A4L9I8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Gamma-crystallin S;
DE   AltName: Full=Beta-crystallin S;
DE   AltName: Full=Gamma-S-crystallin;
GN   Name=CRYGS;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; EF457885; ABO41861.1; -; mRNA.
DR   RefSeq; NP_001093430.1; NM_001099960.1.
DR   AlphaFoldDB; A4L9I8; -.
DR   SMR; A4L9I8; -.
DR   STRING; 9986.ENSOCUP00000015684; -.
DR   Ensembl; ENSOCUT00000028758; ENSOCUP00000015684; ENSOCUG00000022375.
DR   GeneID; 100101573; -.
DR   KEGG; ocu:100101573; -.
DR   CTD; 1427; -.
DR   eggNOG; ENOG502QQAM; Eukaryota.
DR   GeneTree; ENSGT00940000160342; -.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; A4L9I8; -.
DR   OMA; PVEWGAV; -.
DR   OrthoDB; 1225331at2759; -.
DR   Proteomes; UP000001811; Chromosome 14.
DR   Bgee; ENSOCUG00000022375; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P22914"
FT   CHAIN           2..179
FT                   /note="Gamma-crystallin S"
FT                   /id="PRO_0000289612"
FT   DOMAIN          6..44
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          45..87
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          94..134
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          135..177
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          2..5
FT                   /note="N-terminal arm"
FT   REGION          88..93
FT                   /note="Connecting peptide"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P22914"
SQ   SEQUENCE   179 AA;  21128 MW;  2A7A441821F1F900 CRC64;
     MSKTGTKITF YEDKNFQGRR YDCDCDCSDF HTYLSRCNSI RVEGGTWAVY ERPDFAGYMY
     ILPQGDYPEY QRWMGLNDRL SSCRALHLSS GGQYKIQIFE KGDFNGQMYE TTEDCPSIME
     QFHMREIHSC KVLDGAWIFY ELPNYRGRQY LLDKKEYRKP VDWGAVSPAV QSFRRIVES