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CRYPT_CRYDU
ID   CRYPT_CRYDU             Reviewed;          24 AA.
AC   P85028;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Cryptonin;
OS   Cryptotympana dubia (Korean horse cicada).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Auchenorrhyncha; Cicadoidea; Cicadidae;
OC   Cicadinae; Cryptotympanini; Cryptotympana.
OX   NCBI_TaxID=407121;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RX   PubMed=18000874; DOI=10.1002/arch.20213;
RA   Park D.-S., Leem J.Y., Suh E.Y., Hur J.H., Oh H.-W., Park H.-Y.;
RT   "Isolation and functional analysis of a 24-residue linear alpha-helical
RT   antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia
RT   (Homoptera).";
RL   Arch. Insect Biochem. Physiol. 66:204-213(2007).
CC   -!- FUNCTION: Antimicrobial peptide, active against the Gram-negative
CC       bacterium E.coli K12-594 (MIC=3.12 ug/ml), the Gram-positive bacteria
CC       B.subtilis KCTC 3086 (MIC=3.12 ug/ml), S.aureus KCTC 1928 (MIC=25
CC       ug/ml) and M.luteus KCTC 3063 (MIC=1.56 ug/ml), the antibiotic
CC       resistant bacteria methicillin-resistant S.aureus (MRSA) (MIC=25 ug/ml)
CC       and vancomycin-resistant Enterococci (VRE) (MIC=25 ug/ml), and the
CC       fungi C.albicans KCTC 7965 (MIC=50 ug/ml) and C.tropicalis KCTC 1925
CC       (MIC=3.12 ug/ml). Has very low hemolytic activity on rat erythrocytes.
CC       {ECO:0000269|PubMed:18000874}.
CC   -!- MASS SPECTROMETRY: Mass=2704.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18000874};
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DR   AlphaFoldDB; P85028; -.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Fungicide;
KW   Hemolysis.
FT   PEPTIDE         1..24
FT                   /note="Cryptonin"
FT                   /evidence="ECO:0000269|PubMed:18000874"
FT                   /id="PRO_0000320210"
SQ   SEQUENCE   24 AA;  2704 MW;  213DA31F21332031 CRC64;
     GLLNGLALRL GKRALKKIIK RLCR
 
 
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