CRYPT_CRYDU
ID CRYPT_CRYDU Reviewed; 24 AA.
AC P85028;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=Cryptonin;
OS Cryptotympana dubia (Korean horse cicada).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Auchenorrhyncha; Cicadoidea; Cicadidae;
OC Cicadinae; Cryptotympanini; Cryptotympana.
OX NCBI_TaxID=407121;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RX PubMed=18000874; DOI=10.1002/arch.20213;
RA Park D.-S., Leem J.Y., Suh E.Y., Hur J.H., Oh H.-W., Park H.-Y.;
RT "Isolation and functional analysis of a 24-residue linear alpha-helical
RT antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia
RT (Homoptera).";
RL Arch. Insect Biochem. Physiol. 66:204-213(2007).
CC -!- FUNCTION: Antimicrobial peptide, active against the Gram-negative
CC bacterium E.coli K12-594 (MIC=3.12 ug/ml), the Gram-positive bacteria
CC B.subtilis KCTC 3086 (MIC=3.12 ug/ml), S.aureus KCTC 1928 (MIC=25
CC ug/ml) and M.luteus KCTC 3063 (MIC=1.56 ug/ml), the antibiotic
CC resistant bacteria methicillin-resistant S.aureus (MRSA) (MIC=25 ug/ml)
CC and vancomycin-resistant Enterococci (VRE) (MIC=25 ug/ml), and the
CC fungi C.albicans KCTC 7965 (MIC=50 ug/ml) and C.tropicalis KCTC 1925
CC (MIC=3.12 ug/ml). Has very low hemolytic activity on rat erythrocytes.
CC {ECO:0000269|PubMed:18000874}.
CC -!- MASS SPECTROMETRY: Mass=2704.8; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:18000874};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P85028; -.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Fungicide;
KW Hemolysis.
FT PEPTIDE 1..24
FT /note="Cryptonin"
FT /evidence="ECO:0000269|PubMed:18000874"
FT /id="PRO_0000320210"
SQ SEQUENCE 24 AA; 2704 MW; 213DA31F21332031 CRC64;
GLLNGLALRL GKRALKKIIK RLCR