ID   CS012_DANRE             Reviewed;         141 AA.
AC   Q1L990; Q567H5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein C19orf12 homolog;
GN   ORFNames=si:ch211-238a12.2, zgc:112052;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NSK7}.
CC       Mitochondrion membrane {ECO:0000250|UniProtKB:Q9NSK7}; Single-pass
CC       membrane protein {ECO:0000255}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9NSK7}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9NSK7}. Note=In response to oxidative stress,
CC       relocates to the cytosol forming aggregates that partially co-localize
CC       with mitochondria. {ECO:0000250|UniProtKB:Q9NSK7}.
CC   -!- SIMILARITY: Belongs to the C19orf12 family. {ECO:0000305}.
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DR   EMBL; CR381668; CAK04653.1; -; Genomic_DNA.
DR   EMBL; BC093171; AAH93171.1; -; mRNA.
DR   AlphaFoldDB; Q1L990; -.
DR   STRING; 7955.ENSDARP00000076250; -.
DR   PaxDb; Q1L990; -.
DR   PRIDE; Q1L990; -.
DR   Ensembl; ENSDART00000190389; ENSDARP00000155298; ENSDARG00000114095.
DR   ZFIN; ZDB-GENE-050417-151; zgc:112052.
DR   eggNOG; ENOG502RZQC; Eukaryota.
DR   InParanoid; Q1L990; -.
DR   PhylomeDB; Q1L990; -.
DR   PRO; PR:Q1L990; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   Bgee; ENSDARG00000114095; Expressed in musculature of body and 25 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR033369; C19orf12.
DR   PANTHER; PTHR31493; PTHR31493; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Mitochondrion;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..141
FT                   /note="Protein C19orf12 homolog"
FT                   /id="PRO_0000296664"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        66
FT                   /note="K -> T (in Ref. 2; AAH93171)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="G -> S (in Ref. 2; AAH93171)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   141 AA;  14686 MW;  A5AFB216A892A7DA CRC64;
     MPPHVDDVMK LCCELSANQQ VKTAVKQSGK GAAAAGGLAF AGGLIGGPLG IAVGGAVGGL
     LGCWMKSGQF KPLPQVIMEL TPDQQARLYE DIVAILGSIT WTDVAQLTAL VMGNASLQQQ
     VTAALLSYIH KELQAEVHYI D