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CS012_MOUSE
ID   CS012_MOUSE             Reviewed;         141 AA.
AC   Q8WUR0; Q58E27; Q8K308; Q9DAX5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Protein C19orf12 homolog;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic kidney, Olfactory bulb, and Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Liver, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NSK7}.
CC       Mitochondrion membrane {ECO:0000250|UniProtKB:Q9NSK7}; Single-pass
CC       membrane protein {ECO:0000255}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9NSK7}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9NSK7}. Note=In response to oxidative stress,
CC       relocates to the cytosol forming aggregates that partially co-localize
CC       with mitochondria. {ECO:0000250|UniProtKB:Q9NSK7}.
CC   -!- SIMILARITY: Belongs to the C19orf12 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH92099.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK005449; BAB24042.1; -; mRNA.
DR   EMBL; AK032342; BAC27824.1; -; mRNA.
DR   EMBL; AK146474; BAE27199.1; -; mRNA.
DR   EMBL; BC010476; AAH10476.1; -; mRNA.
DR   EMBL; BC019834; AAH19834.1; -; mRNA.
DR   EMBL; BC085480; AAH85480.1; -; mRNA.
DR   EMBL; BC092099; AAH92099.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001078854.1; NM_001085385.1.
DR   RefSeq; NP_082442.1; NM_028166.3.
DR   AlphaFoldDB; Q8WUR0; -.
DR   STRING; 10090.ENSMUSP00000130271; -.
DR   iPTMnet; Q8WUR0; -.
DR   PhosphoSitePlus; Q8WUR0; -.
DR   SwissPalm; Q8WUR0; -.
DR   EPD; Q8WUR0; -.
DR   jPOST; Q8WUR0; -.
DR   MaxQB; Q8WUR0; -.
DR   PaxDb; Q8WUR0; -.
DR   PRIDE; Q8WUR0; -.
DR   Antibodypedia; 47936; 42 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000178207; ENSMUSP00000146124; ENSMUSG00000054676.
DR   Ensembl; ENSMUST00000178876; ENSMUSP00000146135; ENSMUSG00000054676.
DR   Ensembl; ENSMUST00000179503; ENSMUSP00000145884; ENSMUSG00000054676.
DR   Ensembl; ENSMUST00000179525; ENSMUSP00000145694; ENSMUSG00000054676.
DR   Ensembl; ENSMUST00000179992; ENSMUSP00000145679; ENSMUSG00000054676.
DR   GeneID; 72244; -.
DR   KEGG; mmu:72244; -.
DR   UCSC; uc009gks.1; mouse.
DR   MGI; MGI:1919494; 1600014C10Rik.
DR   VEuPathDB; HostDB:ENSMUSG00000054676; -.
DR   eggNOG; ENOG502RZQC; Eukaryota.
DR   GeneTree; ENSGT00390000009077; -.
DR   HOGENOM; CLU_138025_0_0_1; -.
DR   InParanoid; Q8WUR0; -.
DR   OMA; GVAAYKM; -.
DR   OrthoDB; 1474873at2759; -.
DR   PhylomeDB; Q8WUR0; -.
DR   TreeFam; TF323308; -.
DR   BioGRID-ORCS; 72244; 4 hits in 65 CRISPR screens.
DR   PRO; PR:Q8WUR0; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8WUR0; protein.
DR   Bgee; ENSMUSG00000054676; Expressed in urinary bladder urothelium and 227 other tissues.
DR   ExpressionAtlas; Q8WUR0; baseline and differential.
DR   Genevisible; Q8WUR0; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; ISO:MGI.
DR   GO; GO:0006914; P:autophagy; ISO:MGI.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISO:MGI.
DR   GO; GO:0006979; P:response to oxidative stress; ISO:MGI.
DR   InterPro; IPR033369; C19orf12.
DR   PANTHER; PTHR31493; PTHR31493; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Mitochondrion;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..141
FT                   /note="Protein C19orf12 homolog"
FT                   /id="PRO_0000296663"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        2
FT                   /note="P -> S (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8
FT                   /note="I -> V (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        56
FT                   /note="T -> L (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        61
FT                   /note="L -> I (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        73
FT                   /note="V -> I (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        85..86
FT                   /note="QR -> KQ (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91..92
FT                   /note="EA -> QV (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97..98
FT                   /note="GN -> RH (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        124
FT                   /note="M -> I (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        127
FT                   /note="T -> S (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        134..140
FT                   /note="QAEIRYE -> KAKICYG (in Ref. 2; AAH92099)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   141 AA;  15087 MW;  5DC1ED7A8AF54EC1 CRC64;
     MPIMVDDIMR LLCSISQERK MKAAVKHSGK GAMVAGAMAF VGGLVGGPPG IAVGGTVGGL
     LGAWMTSGQF KPVPQILMEL PPAEQRKLVN EAMAIIGNLD WTDAVQLTAL VMSNQAMQQR
     LLAMLTTYVT KELQAEIRYE D
 
 
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