ID   CS018_HUMAN             Reviewed;         215 AA.
AC   Q8NEA5;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Uncharacterized protein C19orf18;
DE   Flags: Precursor;
GN   Name=C19orf18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8NEA5; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-18323646, EBI-714543;
CC       Q8NEA5; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-18323646, EBI-725665;
CC       Q8NEA5; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-18323646, EBI-2858252;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC033933; AAH33933.1; -; mRNA.
DR   CCDS; CCDS12967.1; -.
DR   RefSeq; NP_689687.1; NM_152474.4.
DR   AlphaFoldDB; Q8NEA5; -.
DR   BioGRID; 127073; 18.
DR   IntAct; Q8NEA5; 4.
DR   STRING; 9606.ENSP00000321519; -.
DR   iPTMnet; Q8NEA5; -.
DR   PhosphoSitePlus; Q8NEA5; -.
DR   BioMuta; C19orf18; -.
DR   DMDM; 71153224; -.
DR   MassIVE; Q8NEA5; -.
DR   PaxDb; Q8NEA5; -.
DR   PeptideAtlas; Q8NEA5; -.
DR   PRIDE; Q8NEA5; -.
DR   Antibodypedia; 3045; 114 antibodies from 18 providers.
DR   DNASU; 147685; -.
DR   Ensembl; ENST00000314391.3; ENSP00000321519.2; ENSG00000177025.3.
DR   GeneID; 147685; -.
DR   KEGG; hsa:147685; -.
DR   MANE-Select; ENST00000314391.3; ENSP00000321519.2; NM_152474.5; NP_689687.1.
DR   UCSC; uc002qqv.3; human.
DR   CTD; 147685; -.
DR   DisGeNET; 147685; -.
DR   GeneCards; C19orf18; -.
DR   HGNC; HGNC:28642; C19orf18.
DR   HPA; ENSG00000177025; Tissue enhanced (testis).
DR   neXtProt; NX_Q8NEA5; -.
DR   OpenTargets; ENSG00000177025; -.
DR   PharmGKB; PA134876425; -.
DR   VEuPathDB; HostDB:ENSG00000177025; -.
DR   eggNOG; ENOG502RU2V; Eukaryota.
DR   GeneTree; ENSGT00390000018040; -.
DR   HOGENOM; CLU_112515_0_0_1; -.
DR   InParanoid; Q8NEA5; -.
DR   OMA; FLFLMEC; -.
DR   OrthoDB; 1296700at2759; -.
DR   PhylomeDB; Q8NEA5; -.
DR   TreeFam; TF336996; -.
DR   PathwayCommons; Q8NEA5; -.
DR   SignaLink; Q8NEA5; -.
DR   BioGRID-ORCS; 147685; 14 hits in 1053 CRISPR screens.
DR   ChiTaRS; C19orf18; human.
DR   GenomeRNAi; 147685; -.
DR   Pharos; Q8NEA5; Tdark.
DR   PRO; PR:Q8NEA5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8NEA5; protein.
DR   Bgee; ENSG00000177025; Expressed in sperm and 123 other tissues.
DR   Genevisible; Q8NEA5; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR037549; C19orf18.
DR   PANTHER; PTHR38000; PTHR38000; 1.
DR   Pfam; PF17686; DUF5534; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..215
FT                   /note="Uncharacterized protein C19orf18"
FT                   /id="PRO_0000019567"
FT   TOPO_DOM        30..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          191..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         208
FT                   /note="H -> Y (in dbSNP:rs8110831)"
FT                   /id="VAR_050909"
SQ   SEQUENCE   215 AA;  24151 MW;  F4F449C0F1A7AEDB CRC64;
     MDKVQSGFLI LFLFLMECQL HLCLPYADGL HPTGNITGLP GSKRSQPPRN ITKEPKVFFH
     KTQLPGIQGA ASRSTAASPT NPMKFLRNKA IIRHRPALVK VILISSVAFS IALICGMAIS
     YMIYRLAQAE ERQQLESLYK NLRIPLLGDE EEGSEDEGES THLLPENENE LEKFIHSVII
     SKRSKNIKKK LKEEQNSVTE NKTKNASHNG KMEDL