CS025_HUMAN
ID CS025_HUMAN Reviewed; 118 AA.
AC Q9UFG5; B3KQN6; Q8N9R7; Q8WV94;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=UPF0449 protein C19orf25;
GN Name=C19orf25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thyroid;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9UFG5; P53365: ARFIP2; NbExp=3; IntAct=EBI-741214, EBI-638194;
CC Q9UFG5; Q9UQB8: BAIAP2; NbExp=3; IntAct=EBI-741214, EBI-525456;
CC Q9UFG5; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-741214, EBI-10193358;
CC Q9UFG5; Q494R4-2: CCDC153; NbExp=3; IntAct=EBI-741214, EBI-11974185;
CC Q9UFG5; Q15834: CCDC85B; NbExp=2; IntAct=EBI-741214, EBI-739674;
CC Q9UFG5; O43186: CRX; NbExp=3; IntAct=EBI-741214, EBI-748171;
CC Q9UFG5; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-741214, EBI-742054;
CC Q9UFG5; Q12929: EPS8; NbExp=3; IntAct=EBI-741214, EBI-375576;
CC Q9UFG5; P01100: FOS; NbExp=3; IntAct=EBI-741214, EBI-852851;
CC Q9UFG5; Q2T9L4: INSYN1; NbExp=3; IntAct=EBI-741214, EBI-4311436;
CC Q9UFG5; O95678: KRT75; NbExp=3; IntAct=EBI-741214, EBI-2949715;
CC Q9UFG5; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-741214, EBI-11749135;
CC Q9UFG5; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-741214, EBI-10171774;
CC Q9UFG5; A8MW99: MEI4; NbExp=3; IntAct=EBI-741214, EBI-19944212;
CC Q9UFG5; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-741214, EBI-10172876;
CC Q9UFG5; Q9UL41: PNMA3; NbExp=3; IntAct=EBI-741214, EBI-11278955;
CC Q9UFG5; Q6NUQ1: RINT1; NbExp=4; IntAct=EBI-741214, EBI-726876;
CC Q9UFG5; P21673: SAT1; NbExp=3; IntAct=EBI-741214, EBI-711613;
CC Q9UFG5; P0C1Z6: TFPT; NbExp=3; IntAct=EBI-741214, EBI-1245626;
CC Q9UFG5; P31930: UQCRC1; NbExp=3; IntAct=EBI-741214, EBI-1052596;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UFG5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UFG5-2; Sequence=VSP_020961;
CC -!- SIMILARITY: Belongs to the UPF0449 family. {ECO:0000305}.
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DR EMBL; AK093985; BAC04262.1; -; mRNA.
DR EMBL; AK075267; BAG52098.1; -; mRNA.
DR EMBL; AL122089; CAB59260.2; -; mRNA.
DR EMBL; BC018441; AAH18441.1; -; mRNA.
DR CCDS; CCDS45898.1; -. [Q9UFG5-1]
DR PIR; T34521; T34521.
DR RefSeq; NP_689695.2; NM_152482.2. [Q9UFG5-1]
DR RefSeq; XP_005259563.1; XM_005259506.3. [Q9UFG5-1]
DR RefSeq; XP_006722716.1; XM_006722653.3. [Q9UFG5-1]
DR AlphaFoldDB; Q9UFG5; -.
DR SMR; Q9UFG5; -.
DR BioGRID; 127131; 100.
DR IntAct; Q9UFG5; 45.
DR MINT; Q9UFG5; -.
DR STRING; 9606.ENSP00000397394; -.
DR iPTMnet; Q9UFG5; -.
DR PhosphoSitePlus; Q9UFG5; -.
DR BioMuta; C19orf25; -.
DR DMDM; 74735005; -.
DR EPD; Q9UFG5; -.
DR jPOST; Q9UFG5; -.
DR MassIVE; Q9UFG5; -.
DR MaxQB; Q9UFG5; -.
DR PaxDb; Q9UFG5; -.
DR PeptideAtlas; Q9UFG5; -.
DR PRIDE; Q9UFG5; -.
DR ProteomicsDB; 84183; -. [Q9UFG5-1]
DR ProteomicsDB; 84184; -. [Q9UFG5-2]
DR Antibodypedia; 59259; 29 antibodies from 10 providers.
DR DNASU; 148223; -.
DR Ensembl; ENST00000436106.3; ENSP00000397394.1; ENSG00000119559.17. [Q9UFG5-1]
DR Ensembl; ENST00000585675.6; ENSP00000468688.2; ENSG00000119559.17. [Q9UFG5-1]
DR Ensembl; ENST00000586564.5; ENSP00000466372.1; ENSG00000119559.17. [Q9UFG5-1]
DR Ensembl; ENST00000592872.5; ENSP00000467861.1; ENSG00000119559.17. [Q9UFG5-1]
DR GeneID; 148223; -.
DR KEGG; hsa:148223; -.
DR MANE-Select; ENST00000585675.6; ENSP00000468688.2; NM_152482.3; NP_689695.2.
DR UCSC; uc010dsk.4; human. [Q9UFG5-1]
DR CTD; 148223; -.
DR DisGeNET; 148223; -.
DR GeneCards; C19orf25; -.
DR HGNC; HGNC:26711; C19orf25.
DR HPA; ENSG00000119559; Low tissue specificity.
DR neXtProt; NX_Q9UFG5; -.
DR OpenTargets; ENSG00000119559; -.
DR PharmGKB; PA134878893; -.
DR VEuPathDB; HostDB:ENSG00000119559; -.
DR eggNOG; ENOG502SDTN; Eukaryota.
DR GeneTree; ENSGT00390000007991; -.
DR HOGENOM; CLU_141103_1_0_1; -.
DR InParanoid; Q9UFG5; -.
DR OrthoDB; 1215961at2759; -.
DR PhylomeDB; Q9UFG5; -.
DR TreeFam; TF330719; -.
DR PathwayCommons; Q9UFG5; -.
DR SignaLink; Q9UFG5; -.
DR BioGRID-ORCS; 148223; 196 hits in 1055 CRISPR screens.
DR ChiTaRS; C19orf25; human.
DR GeneWiki; C19orf25; -.
DR GenomeRNAi; 148223; -.
DR Pharos; Q9UFG5; Tdark.
DR PRO; PR:Q9UFG5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UFG5; protein.
DR Bgee; ENSG00000119559; Expressed in C1 segment of cervical spinal cord and 160 other tissues.
DR ExpressionAtlas; Q9UFG5; baseline and differential.
DR Genevisible; Q9UFG5; HS.
DR InterPro; IPR028227; UPF0449.
DR PANTHER; PTHR34766; PTHR34766; 1.
DR Pfam; PF15136; UPF0449; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..118
FT /note="UPF0449 protein C19orf25"
FT /id="PRO_0000252420"
FT COILED 81..109
FT /evidence="ECO:0000255"
FT MOD_RES 63
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9D7E4"
FT VAR_SEQ 83..118
FT /note="LRQRCELLQRAGEDLEREVAQMKQAALPAAEAASSG -> PRLPPQADLSGP
FT AGLGSAQGGLHPGFPWGSVGPRLAFTGSQPTWVLTQAPLLMLGLRFIRRLIHAELVGPT
FT QLAPSCVT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020961"
SQ SEQUENCE 118 AA; 12878 MW; FF3F96AA35398C63 CRC64;
MGSKAKKRVL LPTRPAPPTV EQILEDVRGA PAEDPVFTIL APEDPPVPFR MMEDAEAPGE
QLYQQSRAYV AANQRLQQAG NVLRQRCELL QRAGEDLERE VAQMKQAALP AAEAASSG
