CS044_HUMAN
ID CS044_HUMAN Reviewed; 657 AA.
AC Q9H6X5; Q8N6Y7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized protein C19orf44;
GN Name=C19orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9H6X5; Q8NA61: CBY2; NbExp=3; IntAct=EBI-7112211, EBI-741724;
CC Q9H6X5-2; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-12061599, EBI-11524851;
CC Q9H6X5-2; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-12061599, EBI-10961624;
CC Q9H6X5-2; P63167: DYNLL1; NbExp=5; IntAct=EBI-12061599, EBI-349105;
CC Q9H6X5-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-12061599, EBI-618309;
CC Q9H6X5-2; P37235: HPCAL1; NbExp=4; IntAct=EBI-12061599, EBI-749311;
CC Q9H6X5-2; Q92845: KIFAP3; NbExp=3; IntAct=EBI-12061599, EBI-954040;
CC Q9H6X5-2; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-12061599, EBI-3044087;
CC Q9H6X5-2; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-12061599, EBI-11522433;
CC Q9H6X5-2; P61601: NCALD; NbExp=3; IntAct=EBI-12061599, EBI-749635;
CC Q9H6X5-2; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-12061599, EBI-726876;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H6X5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6X5-2; Sequence=VSP_026311;
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DR EMBL; AK025395; BAB15125.1; -; mRNA.
DR EMBL; BC027869; AAH27869.1; -; mRNA.
DR CCDS; CCDS12345.1; -. [Q9H6X5-1]
DR RefSeq; NP_115583.1; NM_032207.3. [Q9H6X5-1]
DR RefSeq; XP_011526656.1; XM_011528354.2. [Q9H6X5-1]
DR AlphaFoldDB; Q9H6X5; -.
DR BioGRID; 123923; 27.
DR IntAct; Q9H6X5; 15.
DR MINT; Q9H6X5; -.
DR STRING; 9606.ENSP00000221671; -.
DR iPTMnet; Q9H6X5; -.
DR PhosphoSitePlus; Q9H6X5; -.
DR BioMuta; C19orf44; -.
DR DMDM; 74718575; -.
DR EPD; Q9H6X5; -.
DR MassIVE; Q9H6X5; -.
DR MaxQB; Q9H6X5; -.
DR PaxDb; Q9H6X5; -.
DR PeptideAtlas; Q9H6X5; -.
DR PRIDE; Q9H6X5; -.
DR ProteomicsDB; 81055; -. [Q9H6X5-1]
DR ProteomicsDB; 81056; -. [Q9H6X5-2]
DR Antibodypedia; 51085; 65 antibodies from 16 providers.
DR DNASU; 84167; -.
DR Ensembl; ENST00000221671.8; ENSP00000221671.2; ENSG00000105072.9. [Q9H6X5-1]
DR Ensembl; ENST00000593380.1; ENSP00000472255.1; ENSG00000105072.9. [Q9H6X5-2]
DR GeneID; 84167; -.
DR KEGG; hsa:84167; -.
DR MANE-Select; ENST00000221671.8; ENSP00000221671.2; NM_032207.4; NP_115583.1.
DR UCSC; uc002neh.3; human. [Q9H6X5-1]
DR CTD; 84167; -.
DR GeneCards; C19orf44; -.
DR HGNC; HGNC:26141; C19orf44.
DR HPA; ENSG00000105072; Low tissue specificity.
DR neXtProt; NX_Q9H6X5; -.
DR OpenTargets; ENSG00000105072; -.
DR PharmGKB; PA145149498; -.
DR VEuPathDB; HostDB:ENSG00000105072; -.
DR eggNOG; ENOG502RMHR; Eukaryota.
DR GeneTree; ENSGT00390000002505; -.
DR HOGENOM; CLU_028158_0_0_1; -.
DR InParanoid; Q9H6X5; -.
DR OMA; ESKIMNR; -.
DR OrthoDB; 878530at2759; -.
DR PhylomeDB; Q9H6X5; -.
DR TreeFam; TF330762; -.
DR PathwayCommons; Q9H6X5; -.
DR SignaLink; Q9H6X5; -.
DR BioGRID-ORCS; 84167; 15 hits in 1053 CRISPR screens.
DR ChiTaRS; C19orf44; human.
DR GenomeRNAi; 84167; -.
DR Pharos; Q9H6X5; Tdark.
DR PRO; PR:Q9H6X5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H6X5; protein.
DR Bgee; ENSG00000105072; Expressed in oviduct epithelium and 98 other tissues.
DR ExpressionAtlas; Q9H6X5; baseline and differential.
DR Genevisible; Q9H6X5; HS.
DR InterPro; IPR040120; C19orf44-like.
DR InterPro; IPR027884; DUF4614.
DR PANTHER; PTHR22409; PTHR22409; 1.
DR Pfam; PF15391; DUF4614; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..657
FT /note="Uncharacterized protein C19orf44"
FT /id="PRO_0000291921"
FT REGION 142..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXP1"
FT VAR_SEQ 580..657
FT /note="LTAYSPAVLALHDVLKQQLSLTQQFIQASRHLHASLLRSLDADSFHYHTLEE
FT AKEYIRCHRPAPLTMEDALEEVNKEL -> AEPDAAVHPGQPAPARLPPALPGRGLLPL
FT PHPGGSQRVH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026311"
SQ SEQUENCE 657 AA; 71343 MW; 592D9C0792A35CB8 CRC64;
MASARKASRP MRDVFGDFSD VSLEDSTMEE IRNFQISRNL TKIAPGHSRF LKRNQTLDEK
HLLLKENPVL GSGPRLASCR PPTTASRIRA NAALMKLAQL ETRIMNRKLQ RNLSDTESDS
MTADAGLPKR ADRILSGGAL ELASQNTDKT SQNQARELPV TENNAQNAKV SRFLKKKQAP
VENISPEAPA GKERTLQTPK QKEPARTFDS PDSDEEEMKV LLGSLMDSSR EKNTNQGFSS
ANVSEEEERK LFSVPSQLRA FTVPSVELSS AKPSQTSHLP TSLAADRTLH STRSRADYPQ
SHVSSDTASH TPSVSITGAF SNSVSLKMGH VKLVSSPGRS EAETVDEPVS EGADDSLDEF
RINILSLDGL APAVSENSDL EQEEESAQRQ KTAGKIFRAE ASTGQDAPRQ AQARSWASQG
KAASAEGDES EVSEHLSASS ASAIQQDSTS SMQPPSEAPM VNTVSSAYSE DFENSPSLTA
SEPTAHSKES LDRTLDALSE SSSSVKTDLP QTAESRKKSG RHVTRVLVKD TAVQTPDPAF
TYEWTKVASM AAMGPALGGA YVDPTPIANH VISADAIEAL TAYSPAVLAL HDVLKQQLSL
TQQFIQASRH LHASLLRSLD ADSFHYHTLE EAKEYIRCHR PAPLTMEDAL EEVNKEL
