CS047_HUMAN
ID CS047_HUMAN Reviewed; 422 AA.
AC Q8N9M1; Q8IZ33; Q8N0V9;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Uncharacterized protein C19orf47;
GN Name=C19orf47;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Glial tumor;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND SER-126, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-151; SER-306 AND
RP SER-351, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-250, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q8N9M1; Q9P121: NTM; NbExp=3; IntAct=EBI-2835503, EBI-4315078;
CC Q8N9M1-2; O15499: GSC2; NbExp=3; IntAct=EBI-10979594, EBI-19954058;
CC Q8N9M1-2; P60900: PSMA6; NbExp=3; IntAct=EBI-10979594, EBI-357793;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N9M1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N9M1-2; Sequence=VSP_026275;
CC Name=3;
CC IsoId=Q8N9M1-3; Sequence=VSP_026276;
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DR EMBL; AK094207; BAC04311.1; -; mRNA.
DR EMBL; AL834131; CAD38848.1; -; mRNA.
DR EMBL; BC023623; AAH23623.1; -; mRNA.
DR EMBL; BC027935; AAH27935.1; -; mRNA.
DR CCDS; CCDS58662.1; -. [Q8N9M1-1]
DR RefSeq; NP_001243369.1; NM_001256440.1. [Q8N9M1-1]
DR RefSeq; NP_001243370.1; NM_001256441.1.
DR RefSeq; XP_016881784.1; XM_017026295.1. [Q8N9M1-3]
DR AlphaFoldDB; Q8N9M1; -.
DR SMR; Q8N9M1; -.
DR BioGRID; 125997; 25.
DR IntAct; Q8N9M1; 12.
DR STRING; 9606.ENSP00000463159; -.
DR iPTMnet; Q8N9M1; -.
DR PhosphoSitePlus; Q8N9M1; -.
DR BioMuta; C19orf47; -.
DR DMDM; 74729722; -.
DR EPD; Q8N9M1; -.
DR jPOST; Q8N9M1; -.
DR MassIVE; Q8N9M1; -.
DR MaxQB; Q8N9M1; -.
DR PaxDb; Q8N9M1; -.
DR PeptideAtlas; Q8N9M1; -.
DR PRIDE; Q8N9M1; -.
DR ProteomicsDB; 72556; -. [Q8N9M1-1]
DR ProteomicsDB; 72557; -. [Q8N9M1-2]
DR ProteomicsDB; 72558; -. [Q8N9M1-3]
DR Antibodypedia; 30505; 112 antibodies from 17 providers.
DR DNASU; 126526; -.
DR Ensembl; ENST00000392035.6; ENSP00000375889.2; ENSG00000160392.14. [Q8N9M1-2]
DR Ensembl; ENST00000582783.5; ENSP00000463159.1; ENSG00000160392.14. [Q8N9M1-1]
DR GeneID; 126526; -.
DR KEGG; hsa:126526; -.
DR UCSC; uc002onh.5; human. [Q8N9M1-1]
DR CTD; 126526; -.
DR DisGeNET; 126526; -.
DR GeneCards; C19orf47; -.
DR HGNC; HGNC:26723; C19orf47.
DR HPA; ENSG00000160392; Group enriched (heart muscle, skeletal muscle, tongue).
DR neXtProt; NX_Q8N9M1; -.
DR OpenTargets; ENSG00000160392; -.
DR PharmGKB; PA145149543; -.
DR VEuPathDB; HostDB:ENSG00000160392; -.
DR eggNOG; KOG3930; Eukaryota.
DR GeneTree; ENSGT00390000005773; -.
DR HOGENOM; CLU_047260_0_0_1; -.
DR InParanoid; Q8N9M1; -.
DR OMA; DHRIQKN; -.
DR OrthoDB; 1034351at2759; -.
DR PhylomeDB; Q8N9M1; -.
DR TreeFam; TF317361; -.
DR PathwayCommons; Q8N9M1; -.
DR SignaLink; Q8N9M1; -.
DR BioGRID-ORCS; 126526; 12 hits in 1053 CRISPR screens.
DR ChiTaRS; C19orf47; human.
DR GenomeRNAi; 126526; -.
DR Pharos; Q8N9M1; Tdark.
DR PRO; PR:Q8N9M1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N9M1; protein.
DR Bgee; ENSG00000160392; Expressed in apex of heart and 99 other tissues.
DR ExpressionAtlas; Q8N9M1; baseline and differential.
DR Genevisible; Q8N9M1; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR CDD; cd09531; SAM_CS047; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR039161; C19orf47-like.
DR InterPro; IPR040772; C19orf47_SAM.
DR InterPro; IPR041477; DUF5577.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR21359; PTHR21359; 1.
DR Pfam; PF17740; DUF5577; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..422
FT /note="Uncharacterized protein C19orf47"
FT /id="PRO_0000291860"
FT REGION 144..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 126
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 250
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..141
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026276"
FT VAR_SEQ 1..67
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_026275"
SQ SEQUENCE 422 AA; 44746 MW; EA532718B56E24DE CRC64;
MVMAALSLVA ACWGRAAADE SVQLPAAPGS SVRARETMVS VTMATSEWIQ FFKEAGIPPG
PAVNYAVMFV DNRIQKSMLL DLNKEIMNEL GVTVVGDIIA ILKHAKVVHR QDMCKAATES
VPCSPSPLAG EIRRGTSAAS RMITNSLNHD SPPSTPPRRP DTSTSKISVT VSNKMAAKSA
KATAALARRE EESLAVPAKR RRVTAEMEGK YVINMPKGTT PRTRKILEQQ QAAKGLHRTS
VFDRLGAETK ADTTTGSKPT GVFSRLGATP ETDEDLAWDS DNDSSSSVLQ YAGVLKKLGR
GPAKASPQPA LTVKAKATSS ATTAAAPTLR RLALSSRSGL ERKPESLSKV SIIKRLGAAA
LVPEAQDSQV TSTKSKSSAE VKVTIKRTLV GPRGSSSSEG LGAQMDHAGT VSVFKRLGRR
TF
