ID   CS067_HUMAN             Reviewed;         358 AA.
AC   A6NJJ6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 3.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=UPF0575 protein C19orf67;
GN   Name=C19orf67;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SIMILARITY: Belongs to the UPF0575 family. {ECO:0000305}.
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DR   EMBL; AC022098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59360.1; -.
DR   RefSeq; NP_001264307.1; NM_001277378.1.
DR   AlphaFoldDB; A6NJJ6; -.
DR   STRING; 9606.ENSP00000449137; -.
DR   iPTMnet; A6NJJ6; -.
DR   PhosphoSitePlus; A6NJJ6; -.
DR   BioMuta; C19orf67; -.
DR   MassIVE; A6NJJ6; -.
DR   PaxDb; A6NJJ6; -.
DR   PRIDE; A6NJJ6; -.
DR   ProteomicsDB; 1341; -.
DR   Antibodypedia; 67019; 26 antibodies from 7 providers.
DR   DNASU; 646457; -.
DR   Ensembl; ENST00000548523.6; ENSP00000449137.1; ENSG00000188032.10.
DR   Ensembl; ENST00000673482.1; ENSP00000500362.1; ENSG00000288239.1.
DR   GeneID; 646457; -.
DR   KEGG; hsa:646457; -.
DR   MANE-Select; ENST00000548523.6; ENSP00000449137.1; NM_001277378.2; NP_001264307.1.
DR   UCSC; uc031rjr.2; human.
DR   CTD; 646457; -.
DR   GeneCards; C19orf67; -.
DR   HGNC; HGNC:34354; C19orf67.
DR   HPA; ENSG00000188032; Tissue enriched (testis).
DR   neXtProt; NX_A6NJJ6; -.
DR   OpenTargets; ENSG00000188032; -.
DR   VEuPathDB; HostDB:ENSG00000188032; -.
DR   eggNOG; ENOG502R1CJ; Eukaryota.
DR   GeneTree; ENSGT00390000009916; -.
DR   InParanoid; A6NJJ6; -.
DR   OMA; CGDPSWS; -.
DR   OrthoDB; 855013at2759; -.
DR   TreeFam; TF337776; -.
DR   PathwayCommons; A6NJJ6; -.
DR   SignaLink; A6NJJ6; -.
DR   BioGRID-ORCS; 646457; 39 hits in 1035 CRISPR screens.
DR   GenomeRNAi; 646457; -.
DR   Pharos; A6NJJ6; Tdark.
DR   PRO; PR:A6NJJ6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NJJ6; protein.
DR   Bgee; ENSG00000188032; Expressed in left testis and 58 other tissues.
DR   ExpressionAtlas; A6NJJ6; baseline and differential.
DR   InterPro; IPR021748; DUF3314.
DR   PANTHER; PTHR36292; PTHR36292; 1.
DR   Pfam; PF11771; DUF3314; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..358
FT                   /note="UPF0575 protein C19orf67"
FT                   /id="PRO_0000332937"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..47
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  39779 MW;  3A76AB4C24A43203 CRC64;
     MATEQWFEGS LPLDPGETPP PDALEPGTPP CGDPSRSTPP GRPGNPSEPD PEDAEGRLAE
     ARASTSSPKP LVPRPGPAPP RLSLDTLFSP ITQQLRYLLK KADDFQSYLL YSRDQVQKEQ
     LAKAMPTFLQ MCEPYFLYLE AAARSIPPIY GPLQELVRKG LLEISQQLTL RLEQLVLMYA
     SFGFVDLEEM NPLSISCFFC GRFSISLSHE VSIFRYCAPT AYTASRFPRY LYKKMRWHLE
     ATPEAPGRGQ DSLVDYYFLC YRDTWEDTGQ SPANSCPQIQ KLWSIGRWVP LGPAEDDLYS
     WILCPQPLGD YQQLLTIGFE EPTPTLATDL LVQILTGQAG QARPPSAAGP AGWAAQGS