CS073_HUMAN
ID CS073_HUMAN Reviewed; 129 AA.
AC Q9NVV2; Q6NSX4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Putative uncharacterized protein C19orf73;
GN Name=C19orf73;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-106.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-106.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-106.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NVV2; Q15323: KRT31; NbExp=3; IntAct=EBI-2859285, EBI-948001;
CC Q9NVV2; Q6A162: KRT40; NbExp=3; IntAct=EBI-2859285, EBI-10171697;
CC Q9NVV2; Q12800: TFCP2; NbExp=3; IntAct=EBI-2859285, EBI-717422;
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DR EMBL; AK001352; BAA91643.1; -; mRNA.
DR EMBL; AC008687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471177; EAW52456.1; -; Genomic_DNA.
DR EMBL; BC051004; AAH51004.1; -; mRNA.
DR EMBL; BC069669; AAH69669.1; -; mRNA.
DR EMBL; BC069693; AAH69693.1; -; mRNA.
DR EMBL; BC069712; AAH69712.1; -; mRNA.
DR EMBL; BC069750; AAH69750.1; -; mRNA.
DR CCDS; CCDS42589.1; -.
DR RefSeq; NP_060581.2; NM_018111.2.
DR AlphaFoldDB; Q9NVV2; -.
DR BioGRID; 120453; 3.
DR IntAct; Q9NVV2; 4.
DR STRING; 9606.ENSP00000386230; -.
DR BioMuta; C19orf73; -.
DR PaxDb; Q9NVV2; -.
DR PeptideAtlas; Q9NVV2; -.
DR PRIDE; Q9NVV2; -.
DR Antibodypedia; 56430; 24 antibodies from 10 providers.
DR DNASU; 55150; -.
DR Ensembl; ENST00000408991.4; ENSP00000386230.2; ENSG00000221916.4.
DR GeneID; 55150; -.
DR KEGG; hsa:55150; -.
DR MANE-Select; ENST00000408991.4; ENSP00000386230.2; NM_018111.3; NP_060581.2.
DR UCSC; uc002pmq.4; human.
DR CTD; 55150; -.
DR GeneCards; C19orf73; -.
DR HGNC; HGNC:25534; C19orf73.
DR HPA; ENSG00000221916; Low tissue specificity.
DR neXtProt; NX_Q9NVV2; -.
DR OpenTargets; ENSG00000221916; -.
DR PharmGKB; PA164717000; -.
DR VEuPathDB; HostDB:ENSG00000221916; -.
DR eggNOG; ENOG502TGVD; Eukaryota.
DR GeneTree; ENSGT00390000010781; -.
DR HOGENOM; CLU_1964645_0_0_1; -.
DR InParanoid; Q9NVV2; -.
DR OMA; FRKDALW; -.
DR OrthoDB; 1355699at2759; -.
DR PhylomeDB; Q9NVV2; -.
DR TreeFam; TF340718; -.
DR PathwayCommons; Q9NVV2; -.
DR SignaLink; Q9NVV2; -.
DR BioGRID-ORCS; 55150; 7 hits in 1043 CRISPR screens.
DR GenomeRNAi; 55150; -.
DR Pharos; Q9NVV2; Tdark.
DR PRO; PR:Q9NVV2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NVV2; protein.
DR Bgee; ENSG00000221916; Expressed in mucosa of transverse colon and 88 other tissues.
DR Genevisible; Q9NVV2; HS.
DR InterPro; IPR040779; DUF5538.
DR Pfam; PF17692; DUF5538; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..129
FT /note="Putative uncharacterized protein C19orf73"
FT /id="PRO_0000348438"
FT REGION 34..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 106
FT /note="S -> G (in dbSNP:rs2232003)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_046164"
SQ SEQUENCE 129 AA; 13750 MW; D33877940914EC37 CRC64;
MRLKVGFQGG GCFRKDALCL EGGVSARWAR APHSAPLRPP RELHAAPPPA TPTQTVVRPA
GFPRRTRLMV RSAPPTQRPP TGSGCVSGLW RKGLGLRPQT LLRVGSVVLS SAPALRPRLG
PCLRPPPSD
