ID   CS111_CANAL             Reviewed;         743 AA.
AC   Q5APS5; A0A1D8PES1; Q5AP82;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=F-box protein COS111;
GN   Name=COS111; OrderedLocusNames=CAALFM_C110140CA;
GN   ORFNames=CaO19.12346, CaO19.4883;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: F-box protein probably involved in ubiquitin conjugation
CC       pathway. {ECO:0000250}.
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DR   EMBL; CP017623; AOW26644.1; -; Genomic_DNA.
DR   RefSeq; XP_723566.1; XM_718473.2.
DR   AlphaFoldDB; Q5APS5; -.
DR   STRING; 237561.Q5APS5; -.
DR   PRIDE; Q5APS5; -.
DR   GeneID; 3634780; -.
DR   KEGG; cal:CAALFM_C110140CA; -.
DR   CGD; CAL0000176152; orf19.12346.
DR   VEuPathDB; FungiDB:C1_10140C_A; -.
DR   eggNOG; ENOG502R67H; Eukaryota.
DR   HOGENOM; CLU_394915_0_0_1; -.
DR   InParanoid; Q5APS5; -.
DR   OrthoDB; 401409at2759; -.
DR   PRO; PR:Q5APS5; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..743
FT                   /note="F-box protein COS111"
FT                   /id="PRO_0000279192"
FT   DOMAIN          145..191
FT                   /note="F-box"
FT   REGION          224..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..245
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  85000 MW;  25241C71F6E6D561 CRC64;
     MLKTDSLDFH SYLPPYRSLI NPNARYDYRT HSLIPLTQND LNLLRIAFQK KKEAPPSAFK
     MKYKSLLSDV SRTISMRLSN SNLLSSSSAN NNNVLLSPPP SSSSTLSTPC GNILNRAGTT
     SSNISKINNL SQNQTQNQLP LFPAELHIKN LPVEILDYIF YLVDDNLDYK SCMYTCKLFY
     FLAKPYYYEN LVFTSTYRFA QFVTYLRVNS EVGQYVQSID LSGIKPGYDE DEQEEGQEEN
     AENGEEENGG GARDPQYLLG EIADNPHHER VDQFPRGKIL AGWRDWKFKN NPLYTIHPSP
     SLTKIASNSQ FSNVSSKSSR STSSKSSSST TKKFVKPFRY FKSRKRKMSY SGTTKLERKS
     PRLEQLQLDQ YSSNWNKRVN SHPLINKFLL HYSTSKDLPI GYILHMINLC PNIVSLNLGN
     LSLSTDYEIS RSTIHKYQNF DLINNYPKDL IYKVDNIMRL NDVDDVYSID GSILRFGNIN
     SGSSGSNWER NGSSSNNRIL FKSNQSIAST ASSVYSVTTF SKPIRKYNSL LPPLPQTVAD
     ISYLNKGDGK VYLSDLNLKE INSAYLKKIN EDEILSAIIN VHGKRLIEYD TSLYQIPKPL
     NVDIAGTLKY INLSSMIWLN RKLIEKFLTR LLTKKSPELD MYGICYTDEF FDSDEQESDD
     DYEDSDDEEQ RQCPIIYKQN LVIDFTDSGM YKSLPWAKRI DLNSFEGCQL ANKIINNDLM
     TPQEQALRRE RRRRGAIAAN YLA