CS111_DEBHA
ID CS111_DEBHA Reviewed; 615 AA.
AC Q6BWC2;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=F-box protein COS111;
GN Name=COS111; OrderedLocusNames=DEHA2B12474g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: F-box protein probably involved in ubiquitin conjugation
CC pathway. {ECO:0000250}.
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DR EMBL; CR382134; CAG85501.2; -; Genomic_DNA.
DR RefSeq; XP_457497.2; XM_457497.1.
DR AlphaFoldDB; Q6BWC2; -.
DR STRING; 4959.XP_457497.2; -.
DR PRIDE; Q6BWC2; -.
DR EnsemblFungi; CAG85501; CAG85501; DEHA2B12474g.
DR GeneID; 2913449; -.
DR KEGG; dha:DEHA2B12474g; -.
DR VEuPathDB; FungiDB:DEHA2B12474g; -.
DR eggNOG; ENOG502R67H; Eukaryota.
DR HOGENOM; CLU_394915_0_0_1; -.
DR InParanoid; Q6BWC2; -.
DR OMA; KMKYKSL; -.
DR OrthoDB; 401409at2759; -.
DR Proteomes; UP000000599; Chromosome B.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..615
FT /note="F-box protein COS111"
FT /id="PRO_0000279194"
FT DOMAIN 91..137
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 172..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 70565 MW; 62622C03F6217158 CRC64;
MIKTESIDFH SYLPPYRSLL TPNARYDYKT HTLVPIKEHD LRALTSMNLG GKHTTTSKIK
MKYKSLLSDV SKRTSILSLR IGSTANAKQT PIGVKSLPSE VLEYIFELVD SEEAYINCML
VCKQFYQVSK PFLYEDLSFT STYRFAQFIT YLRVNPEVGQ YIKSVDLSQI KHGEPDDYED
ENRELEQTHT STSHGDSDTL NSVSRILAGW RDWKYKNNPL YSIQPYLNLT KVNSNSQTSS
KSSKTTNSMK MLRLSKTLSY FKPKKRQKLN SSRNKNRAHP PLQTLNLGNR RNNSHPQINK
FLMNYSASKD LPIGYILHLI SLCPNIISLN LGNLSLSTDY EISRSMMYKF RTFDLMDNYP
KETAATINGI MNHNNKSNEE SLFGFNQEKN SFTSLSILNI NDAKSQQLQQ SRQNPTSSAS
SVYSVAFSKP IVKYNSLLPP LPPAIHDLSY MNKGDGKVYL SDLNLKSMNN NYLTKLSENE
ILHAIAKAHS SSDGPYGNRL KYINLSSMIW LTKTSAQRFL DQIVNKCLWE ESYFSDAETV
NSDSDSEIIG QDLVIDLRDS GMYKNLEWAK LIDLNQSEGR RLIKRIINDD VLNTFDEFMR
RERLRRGRIG ENYLN