ID   CS111_KLULA             Reviewed;         726 AA.
AC   Q6CM46;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=F-box protein COS111;
GN   Name=COS111; OrderedLocusNames=KLLA0E23166g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: F-box protein probably involved in ubiquitin conjugation
CC       pathway. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAH00080.1; -; Genomic_DNA.
DR   RefSeq; XP_454993.1; XM_454993.1.
DR   AlphaFoldDB; Q6CM46; -.
DR   STRING; 28985.XP_454993.1; -.
DR   EnsemblFungi; CAH00080; CAH00080; KLLA0_E23079g.
DR   GeneID; 2894382; -.
DR   KEGG; kla:KLLA0_E23079g; -.
DR   eggNOG; ENOG502R67H; Eukaryota.
DR   HOGENOM; CLU_017243_0_0_1; -.
DR   InParanoid; Q6CM46; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..726
FT                   /note="F-box protein COS111"
FT                   /id="PRO_0000279195"
FT   DOMAIN          143..194
FT                   /note="F-box"
FT   REGION          276..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   726 AA;  83464 MW;  320960370AA7F0D6 CRC64;
     MGKTNKNRIK TGISYRSLHL LISANETVKE KREAEQLPAL DNDTQCLMST GKVHILNADY
     SRYGVSVYDK LYGYSSSAAS TIEEEDKGSG DGFKKRYMSL MQGSSQWKSR KLKQKKNAPK
     ASAKAKAFLV RLHSEKRRHE VDFADINCLP EEIICRIIAN LNDADSQRNC LLVSQEWSEC
     AKRIIYKDVK FTSTYRVGQF VTTLRENPQY GKYVESLDLS QLKNGFINDE SSTLENDVSQ
     SSYGFEPPDI AYAGWRDWRY RKNSLYGSEM LSSIHRSRTR RSSDASSMNS SVFSHNYNRT
     RSSSVTSLVS RSTQTAAGSK NVVKRIRKLF SNSFRGKGQQ KTHLHQNNGS GLSTLELKDE
     QFAAGTDSCS LRRSHLPFTN KFFLKYAHLR DLPLGYIIHL LTLCVNLKSI NLSNLSLSPD
     FEIEELEYKR NGYVSFFPEE TEEENLNGLN TFNGDRELTP KFFSDSDKPY HYYKDTQYES
     IIWKLDSSRD NNMFTNRRRS RKKFQLKILT NDDLCEAILS LKHMKHLNVG NVVWLMQRDM
     KRLIVHSMES CIIEDRCLDK IYMNFEGSGL QTNLPLAGQG LLKAMVLLQV ITDMTNNCSD
     DQILEWFELR WIPTFRRVSQ PADLVYLARA CDQLHYVIQS EESPTYTRVG EVLITESHTG
     HYKYEISRNV NNVYLTIQIE NGKPDTITDV KLKECSDRLL ERVSNLRKNQ LLQHTGENFF
     STAGLA