CS111_YEAST
ID CS111_YEAST Reviewed; 924 AA.
AC P38308; D6VQK1;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=F-box protein COS111;
DE AltName: Full=Ciclopirox olamine sensitivity protein 111;
GN Name=COS111; OrderedLocusNames=YBR203W; ORFNames=YBR1443;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8368014; DOI=10.1002/yea.320090714;
RA Bussereau F., Mallet L., Gaillon L., Jacquet M.;
RT "A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces
RT cerevisiae including part of the DUR1,2 gene, contains five putative new
RT genes.";
RL Yeast 9:797-806(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 727-731; 917 AND 921.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION.
RX PubMed=12661761;
RA Leem S.-H., Park J.-E., Kim I.-S., Chae J.-Y., Sugino A., Sunwoo Y.;
RT "The possible mechanism of action of ciclopirox olamine in the yeast
RT Saccharomyces cerevisiae.";
RL Mol. Cells 15:55-61(2003).
CC -!- FUNCTION: F-box protein probably involved in ubiquitin conjugation
CC pathway. Involved in the resistance to ciclopirox olamine (CPO), a
CC synthetic antifungal agent. {ECO:0000269|PubMed:12661761}.
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DR EMBL; Z21487; CAA79691.1; -; Genomic_DNA.
DR EMBL; Z36072; CAA85167.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07321.2; -; Genomic_DNA.
DR PIR; S34926; S34926.
DR RefSeq; NP_009762.2; NM_001178551.2.
DR AlphaFoldDB; P38308; -.
DR BioGRID; 32900; 105.
DR DIP; DIP-4943N; -.
DR IntAct; P38308; 9.
DR STRING; 4932.YBR203W; -.
DR iPTMnet; P38308; -.
DR PaxDb; P38308; -.
DR PRIDE; P38308; -.
DR EnsemblFungi; YBR203W_mRNA; YBR203W; YBR203W.
DR GeneID; 852502; -.
DR KEGG; sce:YBR203W; -.
DR SGD; S000000407; COS111.
DR VEuPathDB; FungiDB:YBR203W; -.
DR eggNOG; ENOG502R67H; Eukaryota.
DR HOGENOM; CLU_017243_0_0_1; -.
DR InParanoid; P38308; -.
DR OMA; LLKYAPY; -.
DR BioCyc; YEAST:G3O-29144-MON; -.
DR PRO; PR:P38308; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38308; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0007165; P:signal transduction; IMP:SGD.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 4: Predicted;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..924
FT /note="F-box protein COS111"
FT /id="PRO_0000202509"
FT DOMAIN 185..236
FT /note="F-box"
FT REGION 35..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 727..731
FT /note="TFRQH -> SWRND (in Ref. 1; CAA79691 and 2;
FT CAA85167)"
FT /evidence="ECO:0000305"
FT CONFLICT 917
FT /note="N -> S (in Ref. 1; CAA79691 and 2; CAA85167)"
FT /evidence="ECO:0000305"
FT CONFLICT 921
FT /note="E -> G (in Ref. 1; CAA79691 and 2; CAA85167)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 924 AA; 104615 MW; 4B3C940BB8FC10DF CRC64;
MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS SISQKSRSKQ
RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR RSDDVTSLDN ETIITMNSRK
SRIKKKYKSL ISTSSKKFMN KLYDHGASSD SFSIFSLKTS HSGKHENSRF EKLRKRKYHA
WGKFADINDL PVEIIAKILS EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR
VAQFVTSLRL HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT
SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE PLYSSPLLNS
FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT TSIMSSIYNT SHVSLSSTTS
NTSNGNISSG SNLSRVSTAG SLKKASAKST RSSPQKAKPI SDITSSSWFR MRLSSRNRKA
RTANTINLKN SKDKSDDDFK VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA
PYKDLPLGYI LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS
AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT DYPPPIDAQT
KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG YCSLTKVKMN DIVWCRQYMV
KYFVMRTFRQ HLDYKSMENN SYERHLFSFR DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN
LDDLGLEELF NIKSEKLYIK NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ
FRLTILKTEK PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR
LKELRRVDLR RNVGENNYYA ESII
