ID   CS2IP_HUMAN             Reviewed;         734 AA.
AC   A0A1B0GTH6;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Casein kinase II subunit alpha'-interacting protein {ECO:0000305};
GN   Name=CSNKA2IP {ECO:0000312|HGNC:HGNC:53637};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- FUNCTION: May play a role in chromatin regulation of male germ cells.
CC       {ECO:0000250|UniProtKB:Q8CH19}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with CSNK2A2.
CC       {ECO:0000250|UniProtKB:Q8CH19}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CH19}.
CC       Note=Present in nuclei of spermatids during chromatin condensation.
CC       {ECO:0000250|UniProtKB:Q8CH19}.
CC   -!- PTM: Phosphorylated by CK2 (casein kinase II), specifically by
CC       complexes containing catalytic subunit CSNK2A2.
CC       {ECO:0000250|UniProtKB:Q8CH19}.
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DR   EMBL; AC108750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC126475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0GTH6; -.
DR   PhosphoSitePlus; A0A1B0GTH6; -.
DR   BioMuta; ENSG00000283434; -.
DR   MassIVE; A0A1B0GTH6; -.
DR   PeptideAtlas; A0A1B0GTH6; -.
DR   Ensembl; ENST00000637986.2; ENSP00000489704.1; ENSG00000283434.2.
DR   MANE-Select; ENST00000637986.2; ENSP00000489704.1; NM_001368165.1; NP_001355094.1.
DR   GeneCards; CSNKA2IP; -.
DR   HGNC; HGNC:53637; CSNKA2IP.
DR   HPA; ENSG00000283434; Tissue enriched (testis).
DR   neXtProt; NX_A0A1B0GTH6; -.
DR   OpenTargets; ENSG00000283434; -.
DR   VEuPathDB; HostDB:ENSG00000283434; -.
DR   GeneTree; ENSGT00390000012239; -.
DR   OMA; SPVCHSK; -.
DR   Pharos; A0A1B0GTH6; Tdark.
DR   PRO; PR:A0A1B0GTH6; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A0A1B0GTH6; protein.
DR   Bgee; ENSG00000283434; Expressed in left testis and 42 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038954; CSNKA2IP.
DR   PANTHER; PTHR35825; PTHR35825; 3.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..734
FT                   /note="Casein kinase II subunit alpha'-interacting protein"
FT                   /id="PRO_0000443085"
FT   REGION          608..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  81798 MW;  31FA7666BA1367D5 CRC64;
     MVPLAYYGQH FVPLDYFYQL SSANTLTHQH TGEKLNQFNN QPMAKVQSHS NHFAVPPLGS
     NKKVQRCSVL PSPKSQDKIS QSFCDRFLNS PLFHAKHQNT PSIGLHWRSS LWPAQRALNS
     HLLHSKAQTT SSSDLNMTSS LELNQAALSL QLPFCKPQTT SSSLDVCWRS LSLKSHQRVS
     SSSLFRLQNQ EIPSINIIWT SSSLGPKRKA LSSTLLQSKP QKTSSLDYLW TSSLQRNQRS
     LSSPSLNTKL QTSDLFWTSP SFKPNQIALT SPLLDSRLQK TPILNSNPTI GGLPVSHSKA
     RQSASSYFVH PSENLPLFQL NSQSMFMLDC NFQTTNSPVC HSKFQNTTSP NGKHRVTHLP
     SPHPKTNISG QLLSSSKHCT RNTAASTLGF RLQSKSSFQF SPKTESNKEI PWTLKYSQPC
     IVKGGTVPDD VVNKIVNSIS NTRIQRDLCR QILFRRMRGR PNPHPGPRLS SNYVVCLACA
     SCLKSPCNHL RGKKNPHCAT LSVIPTPEAN SEGKIEVKLV LILSLPETFS SCLPFPMKEN
     QPNEVPEDNL EGVEKIQQFF PTSERDIQGL NMKQIWWAVA PENKVIGQQP QAIDWLFYVK
     KNNSQPQSLL PSTSSSTSSS STTSSSSSVA SASSDSSSSS SSSSSFSISS SSSPSKEFMT
     LTLSRPVFRK VLSYHRLPAG VSWLEFIYSK DYQLHPRKPN RSQSSSLKTK PVRNNNTVKW
     RKGANTLFKF FRTK