CS2IP_MOUSE
ID CS2IP_MOUSE Reviewed; 720 AA.
AC Q8CH19; A0A1B0GSC5;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Casein kinase II subunit alpha'-interacting protein {ECO:0000312|MGI:MGI:2676295};
DE AltName: Full=CK2 target protein 2 {ECO:0000303|PubMed:19273531};
GN Name=Csnka2ip {ECO:0000312|MGI:MGI:2676295};
GN Synonyms=CKT2 {ECO:0000303|PubMed:19273531};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:EDK98240.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 290-720, FUNCTION, INTERACTION WITH CSNK2A2,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=19273531; DOI=10.1093/nar/gkp094;
RA Bai X., Silvius D., Chan E.D., Escalier D., Xu S.X.;
RT "Identification and characterization of a novel testis-specific gene CKT2,
RT which encodes a substrate for protein kinase CK2.";
RL Nucleic Acids Res. 37:2699-2711(2009).
RN [4] {ECO:0000312|EMBL:AAI37819.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 316-720.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in chromatin regulation of male germ cells.
CC {ECO:0000305|PubMed:19273531}.
CC -!- SUBUNIT: Interacts (via C-terminus) with CSNK2A2.
CC {ECO:0000269|PubMed:19273531}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19273531}.
CC Note=Present in nuclei of spermatids during chromatin condensation.
CC {ECO:0000269|PubMed:19273531}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in testis (at protein level).
CC Within testis, expressed mainly in the intermediate compartment of the
CC seminiferous tubules with weaker expression in the basal and adluminal
CC compartments. {ECO:0000269|PubMed:19273531}.
CC -!- PTM: Phosphorylated by CK2 (casein kinase II), specifically by
CC complexes containing catalytic subunit CSNK2A2.
CC {ECO:0000269|PubMed:19273531}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI37819.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAO15676.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EDK98240.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC154294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC166327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466521; EDK98240.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF463503; AAO15676.1; ALT_INIT; mRNA.
DR EMBL; BC137818; AAI37819.1; ALT_INIT; mRNA.
DR CCDS; CCDS37374.2; -.
DR RefSeq; NP_776286.1; NM_173861.2.
DR RefSeq; XP_006522159.1; XM_006522096.1.
DR RefSeq; XP_006522160.1; XM_006522097.1.
DR RefSeq; XP_011244189.1; XM_011245887.1.
DR AlphaFoldDB; Q8CH19; -.
DR STRING; 10090.ENSMUSP00000086692; -.
DR ChEMBL; CHEMBL3832945; -.
DR iPTMnet; Q8CH19; -.
DR PhosphoSitePlus; Q8CH19; -.
DR PaxDb; Q8CH19; -.
DR PRIDE; Q8CH19; -.
DR ProteomicsDB; 285372; -.
DR Ensembl; ENSMUST00000209382; ENSMUSP00000147880; ENSMUSG00000068167.
DR GeneID; 224291; -.
DR KEGG; mmu:224291; -.
DR UCSC; uc012aha.1; mouse.
DR CTD; 111064647; -.
DR MGI; MGI:2676295; Csnka2ip.
DR VEuPathDB; HostDB:ENSMUSG00000068167; -.
DR eggNOG; ENOG502RQH2; Eukaryota.
DR GeneTree; ENSGT00390000012239; -.
DR HOGENOM; CLU_1158683_0_0_1; -.
DR InParanoid; Q8CH19; -.
DR OMA; SPVCHSK; -.
DR OrthoDB; 353409at2759; -.
DR PhylomeDB; Q8CH19; -.
DR TreeFam; TF339570; -.
DR BioGRID-ORCS; 224291; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Csnka2ip; mouse.
DR PRO; PR:Q8CH19; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8CH19; protein.
DR Bgee; ENSMUSG00000068167; Expressed in testis and 4 other tissues.
DR ExpressionAtlas; Q8CH19; baseline and differential.
DR GO; GO:0001673; C:male germ cell nucleus; IDA:MGI.
DR InterPro; IPR038954; CSNKA2IP.
DR PANTHER; PTHR35825; PTHR35825; 2.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..720
FT /note="Casein kinase II subunit alpha'-interacting protein"
FT /id="PRO_0000436772"
FT REGION 227..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 79205 MW; 6E67948084BDEA58 CRC64;
MVPLGYNNKY FGYVQDCQQQ ATDNSPIHYY TGDKQNQSYS QSMCKEQSQN TVTVSPASFN
KKAQSTQGSY NRAMKSSSSL YSTCSTTPSK DSLLKNSSYP SWKSLDSSLS HHKSETTSLT
SFTSTSSLEP SKISSRSRLL LPKTQTSSSI DLCWKSPSLE SNQRVSTSSS TSVQHHEAPS
LNIIWTTPSL ESNQSEHDSQ LCKSKSQKDS SLDRLWSSLL ESSQKALSSP SFTNRLQRNS
FPPTSSSLEF SRVARNSPLP DCSKPLKIPV SNSNNNVFSL PLSPAKSRKS TPSPHSFLPS
RRLSTCQPKP KIVARCDPST RAINTAVCHP KVQNTASLSD KQRPRQLPSI HPKPNPSGQR
VSSPKPCIKN KIASVPCSRL PNKSSVERSV KTEPENEISW ALDYSHPCII KGGSVPVDVV
NKIINSISKS TIQKDLSRQI LFRRMRGKPN PRPGPRLSST YSVCLECASA IKSQCNHLSG
KRDPRCATLF VIPTPESSTD GKVDVKIILI LSLPEKPSST CFQLPMKDSK SENNLEALDD
NLDVLEKITQ FFPASESDFI QGLKTKRKCL AVSSESKDLS QEPQSIDWLL YVKNSNGIQL
ETQVQGPSSS SSSSCSSVSS SSSASSIGRP SPPTPWVDPT PVPVSGYVLA KVRSYHRLPP
GTSWLEFIRG SSSDTIKLRQ SPPVKAKPVR SHNSKCLKKG KRETSALLRY FQTKFQNEKS
