CS2LA_MOUSE
ID CS2LA_MOUSE Reviewed; 184 AA.
AC Q02862;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Alpha-S2-casein-like A;
DE AltName: Full=Casein alpha S2-like A;
DE AltName: Full=Gamma-casein;
DE AltName: Full=PP22;
DE Flags: Precursor;
GN Name=Csn1s2a; Synonyms=Csng;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-38 AND 172-184, AND
RP PHOSPHORYLATION AT SER-23; SER-24; SER-25 AND SER-37.
RX PubMed=7763793;
RA Sasaki T., Sasaki M., Enami J.;
RT "Mouse gamma-casein cDNA: PCR cloning and sequence analysis.";
RL Zool. Sci. 10:65-72(1993).
CC -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC phosphate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland-specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR EMBL; D10215; BAA01067.1; -; mRNA.
DR CCDS; CCDS39132.1; -.
DR PIR; I49685; I49685.
DR RefSeq; NP_031811.1; NM_007785.2.
DR AlphaFoldDB; Q02862; -.
DR SMR; Q02862; -.
DR STRING; 10090.ENSMUSP00000075716; -.
DR iPTMnet; Q02862; -.
DR PhosphoSitePlus; Q02862; -.
DR CPTAC; non-CPTAC-3456; -.
DR PaxDb; Q02862; -.
DR PeptideAtlas; Q02862; -.
DR PRIDE; Q02862; -.
DR ProteomicsDB; 279067; -.
DR Ensembl; ENSMUST00000076379; ENSMUSP00000075716; ENSMUSG00000061937.
DR GeneID; 12993; -.
DR KEGG; mmu:12993; -.
DR UCSC; uc008xyw.2; mouse.
DR CTD; 12993; -.
DR MGI; MGI:88542; Csn1s2a.
DR VEuPathDB; HostDB:ENSMUSG00000061937; -.
DR GeneTree; ENSGT00940000164399; -.
DR HOGENOM; CLU_1503029_0_0_1; -.
DR InParanoid; Q02862; -.
DR OMA; QRIAMNP; -.
DR OrthoDB; 1489083at2759; -.
DR TreeFam; TF339561; -.
DR BioGRID-ORCS; 12993; 0 hits in 58 CRISPR screens.
DR ChiTaRS; Csn1s2a; mouse.
DR PRO; PR:Q02862; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q02862; protein.
DR Bgee; ENSMUSG00000061937; Expressed in thoracic mammary gland and 64 other tissues.
DR ExpressionAtlas; Q02862; baseline and differential.
DR Genevisible; Q02862; MM.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0035375; F:zymogen binding; IBA:GO_Central.
DR InterPro; IPR011175; Alpha-s2_casein.
DR PANTHER; PTHR16656; PTHR16656; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Milk protein; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000269|PubMed:7763793"
FT CHAIN 16..184
FT /note="Alpha-S2-casein-like A"
FT /id="PRO_0000004467"
FT REGION 49..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:7763793"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:7763793"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:7763793"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:7763793"
SQ SEQUENCE 184 AA; 21101 MW; AE6EC45FD3E24A32 CRC64;
MKFFIFACLV VVALAKHEIK DKSSSEESSA SIYPGKSKLD NSVFFQTTKD SASSSSSEES
SEEVSEKIVQ SEEQKVNLNQ QKKFKQFSQE SSFSQCCTPL HQQQQSSVNQ WPQPNAIHNT
PTQESISTSV EEILKKIIDM IKYIQYQQVT IPQLPQALHP QIPVSYWYPS KDYTFPNAHY
TRFY
