ID   CS2LA_RABIT             Reviewed;         180 AA.
AC   P50418;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Alpha-S2-casein-like A;
DE   AltName: Full=Alpha-S2A-casein;
DE   AltName: Full=Casein alpha S2-like A;
DE   Flags: Precursor;
GN   Name=CSN1S2A;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RX   PubMed=8280077; DOI=10.1042/bj2960777;
RA   Dawson S.P., Wilde C.J., Tighe P.J., Mayer R.J.;
RT   "Characterization of two novel casein transcripts in rabbit mammary
RT   gland.";
RL   Biochem. J. 296:777-784(1993).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X76907; CAA54228.1; -; mRNA.
DR   PIR; S39775; S39775.
DR   RefSeq; NP_001075869.1; NM_001082400.1.
DR   AlphaFoldDB; P50418; -.
DR   SMR; P50418; -.
DR   STRING; 9986.ENSOCUP00000017537; -.
DR   Allergome; 2149; Ory c 8.
DR   PRIDE; P50418; -.
DR   GeneID; 100009287; -.
DR   KEGG; ocu:100009287; -.
DR   CTD; 12993; -.
DR   eggNOG; ENOG502TDWX; Eukaryota.
DR   HOGENOM; CLU_1503029_0_0_1; -.
DR   InParanoid; P50418; -.
DR   OMA; QRIAMNP; -.
DR   OrthoDB; 1489083at2759; -.
DR   TreeFam; TF339561; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..180
FT                   /note="Alpha-S2-casein-like A"
FT                   /id="PRO_0000004455"
FT   REGION          46..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02862"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02862"
SQ   SEQUENCE   180 AA;  21331 MW;  4CD1EBB9F9D1CF53 CRC64;
     MRFFVFTCLL AVALAKNGIE QRSASEEIVS FYQEKYKQDS NAAIYPTNQE TPSVSSSEES
     VEVQTEKDEQ IEEENVYLKQ LKRIKQIFQK FYIPQYPEVY QQQIVMNPWK HVKTTTYPVP
     IPETTRIPLE EIVKKIVEMI KFNQLHQFVI PQYVQALQQR IAMNPWHHVT PFRSFPVLNF