ID   CS2LA_RAT               Reviewed;         179 AA.
AC   P02667;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Alpha-S2-casein-like A;
DE   AltName: Full=Casein alpha S2-like A;
DE   AltName: Full=Gamma-casein;
DE   Flags: Precursor;
GN   Name=Csn1s2a; Synonyms=Csng;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6298707; DOI=10.1093/nar/10.24.8079;
RA   Hobbs A.A., Rosen J.M.;
RT   "Sequence of rat alpha- and gamma-casein mRNAs: evolutionary comparison of
RT   the calcium-dependent rat casein multigene family.";
RL   Nucleic Acids Res. 10:8079-8098(1982).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; J00712; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A03111; KGRT.
DR   AlphaFoldDB; P02667; -.
DR   SMR; P02667; -.
DR   STRING; 10116.ENSRNOP00000057022; -.
DR   Allergome; 2151; Rat n 8.
DR   UCSC; RGD:621152; rat.
DR   RGD; 621152; Csn1s2a.
DR   InParanoid; P02667; -.
DR   PRO; PR:P02667; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0035375; F:zymogen binding; IBA:GO_Central.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..179
FT                   /note="Alpha-S2-casein-like A"
FT                   /id="PRO_0000004468"
FT   REGION          44..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02862"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02862"
SQ   SEQUENCE   179 AA;  20278 MW;  91B3EB95229976FD CRC64;
     MKFFIFTCLV AAALAKHAVK DKPSSEESAS VYLGKYKQGN SVFFQTPQDS ASSSSSEESS
     EEISEKIEQS EEQKVNLNQQ KKSKQFSQDS SFPQICTPYQ QQSSVNQRPQ PNAIYDVPSQ
     ESTSTSVEEI LKKIIDIVKY FQYQQLTNPH FPQAVHPQIR VSSWAPSKDY TFPTARYMA