CS2LB_MOUSE
ID CS2LB_MOUSE Reviewed; 143 AA.
AC P02664; Q3TP28; Q3TP29; Q542L5;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Alpha-S2-casein-like B;
DE AltName: Full=Casein alpha S2-like B;
DE AltName: Full=Epsilon-casein;
DE Flags: Precursor;
GN Name=Csn1s2b; Synonyms=Csnd, Csne;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6897225; DOI=10.1111/j.1432-1033.1982.tb06818.x;
RA Hennighausen L.G., Steudle A., Sippel A.E.;
RT "Nucleotide sequence of cloned cDNA coding for mouse epsilon casein.";
RL Eur. J. Biochem. 126:569-572(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC phosphate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR EMBL; V00740; CAA24114.1; -; mRNA.
DR EMBL; J00379; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK021337; BAB32379.1; -; mRNA.
DR EMBL; AK052780; BAC35144.1; -; mRNA.
DR EMBL; AK085744; BAC39528.1; -; mRNA.
DR EMBL; AK085747; BAC39529.1; -; mRNA.
DR EMBL; AK164767; BAE37908.1; -; mRNA.
DR EMBL; AK164768; BAE37909.1; -; mRNA.
DR EMBL; AK164795; BAE37921.1; -; mRNA.
DR EMBL; BC002084; AAH02084.1; -; mRNA.
DR CCDS; CCDS39133.1; -.
DR PIR; A03108; KEMS.
DR RefSeq; NP_001288263.1; NM_001301334.1.
DR RefSeq; NP_001288264.1; NM_001301335.1.
DR RefSeq; NP_034103.2; NM_009973.3.
DR AlphaFoldDB; P02664; -.
DR SMR; P02664; -.
DR STRING; 10090.ENSMUSP00000072352; -.
DR iPTMnet; P02664; -.
DR PhosphoSitePlus; P02664; -.
DR PaxDb; P02664; -.
DR PRIDE; P02664; -.
DR Ensembl; ENSMUST00000072539; ENSMUSP00000072352; ENSMUSG00000061388.
DR GeneID; 12992; -.
DR KEGG; mmu:12992; -.
DR UCSC; uc008xyz.3; mouse.
DR CTD; 12992; -.
DR MGI; MGI:105312; Csn1s2b.
DR VEuPathDB; HostDB:ENSMUSG00000061388; -.
DR eggNOG; ENOG502TDWX; Eukaryota.
DR GeneTree; ENSGT00940000164399; -.
DR InParanoid; P02664; -.
DR OMA; VMNPWDQ; -.
DR OrthoDB; 587717at2759; -.
DR PhylomeDB; P02664; -.
DR TreeFam; TF339561; -.
DR BioGRID-ORCS; 12992; 3 hits in 71 CRISPR screens.
DR PRO; PR:P02664; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P02664; protein.
DR Bgee; ENSMUSG00000061388; Expressed in hindlimb stylopod muscle and 12 other tissues.
DR ExpressionAtlas; P02664; baseline and differential.
DR Genevisible; P02664; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0035375; F:zymogen binding; IBA:GO_Central.
DR InterPro; IPR011175; Alpha-s2_casein.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR031305; Casein_CS.
DR PANTHER; PTHR16656; PTHR16656; 2.
DR Pfam; PF00363; Casein; 1.
DR PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Milk protein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..143
FT /note="Alpha-S2-casein-like B"
FT /id="PRO_0000004466"
FT CONFLICT 10
FT /note="L -> W (in Ref. 2; BAE37908)"
FT /evidence="ECO:0000305"
FT CONFLICT 20
FT /note="E -> G (in Ref. 2; BAE37909)"
FT /evidence="ECO:0000305"
FT CONFLICT 31
FT /note="N -> T (in Ref. 1; CAA24114)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 143 AA; 16911 MW; 410B47DE3DD49744 CRC64;
MKFIILTCLL AVALAKQRME QYISSEESMD NSQENFKQNM DVAFFPSQET VENIYIPQME
SVEAPMKVSD IISQQQYNQK MMDMSVSARE KTVMTEESKN IQDYMNKMKR YSKITWPQFV
KLLHQYQKTM TPWSYYPSTP SQV
