ID   CS2LB_RAT               Reviewed;         169 AA.
AC   Q8CGR3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Alpha-S2-casein-like B;
DE   AltName: Full=Casein alpha S2-like B;
DE   AltName: Full=Delta-casein;
DE   Flags: Precursor;
GN   Name=Csn1s2b; Synonyms=Csnd;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Lactating mammary gland;
RX   PubMed=13679022; DOI=10.1016/s0888-7543(03)00114-9;
RA   Rijnkels M., Elnitski L., Miller W., Rosen J.M.;
RT   "Multispecies comparative analysis of a mammalian-specific genomic domain
RT   encoding secretory proteins.";
RL   Genomics 82:417-432(2003).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; AY154894; AAN85582.1; -; mRNA.
DR   RefSeq; NP_775129.1; NM_173106.1.
DR   AlphaFoldDB; Q8CGR3; -.
DR   SMR; Q8CGR3; -.
DR   STRING; 10116.ENSRNOP00000057030; -.
DR   iPTMnet; Q8CGR3; -.
DR   PhosphoSitePlus; Q8CGR3; -.
DR   PaxDb; Q8CGR3; -.
DR   GeneID; 286759; -.
DR   KEGG; rno:286759; -.
DR   UCSC; RGD:628794; rat.
DR   CTD; 12992; -.
DR   RGD; 628794; Csn1s2b.
DR   InParanoid; Q8CGR3; -.
DR   OrthoDB; 1489083at2759; -.
DR   PhylomeDB; Q8CGR3; -.
DR   TreeFam; TF339561; -.
DR   PRO; PR:Q8CGR3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0035375; F:zymogen binding; IBA:GO_Central.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..169
FT                   /note="Alpha-S2-casein-like B"
FT                   /id="PRO_0000269037"
SQ   SEQUENCE   169 AA;  19846 MW;  220477182334E986 CRC64;
     MKFIILTCLL AVALAKQESK DNSQEDFKQT VDVVIFPGQE TVKNIPIPQM ESVEAPIKNK
     CYQSIQTFKP PQALKGLYQY HMAKNPWGYT VNRAFPSTRT LQYNQKTMDL SMRAREKIVM
     SEIKKNIQDY VTKMKQYSKI TWPRFVKSLQ QYQKTMNPWS CYPYTLLQV