ID   CS72_SALH5              Reviewed;          67 AA.
AC   P0DV90;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Retron Se72 cold shock-like protein {ECO:0000303|PubMed:33157039};
GN   ORFNames=Ga0072986_12845, SEEH8310_20094 {ECO:0000303|Ref.1};
OS   Salmonella heidelberg (strain 579083-10).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=1054962;
RN   [1] {ECO:0000312|EMBL:KJT75255.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=579083-10;
RA   Timme R.E., Allard M., Luo Y., Strain E., Pettengill J., Li C., Ottesen A.,
RA   Brown E.;
RT   "Serovar diversity of Salmonella subsp. enterica.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION IN ANTIVIRAL DEFENSE, AND IDENTIFICATION AS A RETRON.
RC   STRAIN=579083-10;
RX   PubMed=33157039; DOI=10.1016/j.cell.2020.09.065;
RA   Millman A., Bernheim A., Stokar-Avihail A., Fedorenko T., Voichek M.,
RA   Leavitt A., Oppenheimer-Shaanan Y., Sorek R.;
RT   "Bacterial Retrons Function In Anti-Phage Defense.";
RL   Cell 183:1551-1561(2020).
CC   -!- FUNCTION: Probable cold shock-like component of antiviral defense
CC       system retron Se72, composed of a non-coding RNA (ncRNA), a reverse
CC       transcriptase (RT) and this protein. Expression of retron Se72 confers
CC       protection against bacteriophage lambda. At multiplicity of infection
CC       (MOI) of 0.02 cultures slow growth when infected with lambda but do not
CC       collapse, at MOI 2 cultures enter growth stasis.
CC       {ECO:0000269|PubMed:33157039}.
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DR   EMBL; AMMS01000284; KJT75255.1; -; Genomic_DNA.
DR   PROSITE; PS51857; CSD_2; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense.
FT   CHAIN           1..67
FT                   /note="Retron Se72 cold shock-like protein"
FT                   /id="PRO_0000456023"
FT   DOMAIN          1..66
FT                   /note="CSD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01204"
SQ   SEQUENCE   67 AA;  7966 MW;  B9A9C248C494D7CF CRC64;
     MENGFVNFYD HVKGYGFIRR ERGRDVFFRY DDFLFLGHDV DICKGILVRF KLEKTDKGFK
     AVAIQKV