ID   CS81_CONAH              Reviewed;          92 AA.
AC   B2CI28;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Conotoxin Ac8.1;
DE   Flags: Precursor; Fragment;
OS   Conus achatinus (Little frog cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=369967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=18423793; DOI=10.1016/j.toxicon.2008.03.001;
RA   Liu L., Wu X., Yuan D., Chi C., Wang C.;
RT   "Identification of a novel S-superfamily conotoxin from vermivorous Conus
RT   caracteristicus.";
RL   Toxicon 51:1331-1337(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is VIII (C-C-C-C-C-C-C-C-C-C).
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin S superfamily. {ECO:0000305}.
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DR   EMBL; EU496107; ACA63847.1; -; mRNA.
DR   AlphaFoldDB; B2CI28; -.
DR   ConoServer; 2822; Ac8.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Neurotoxin; Pyrrolidone carboxylic acid; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          <1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..44
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000346131"
FT   PEPTIDE         45..92
FT                   /note="Conotoxin Ac8.1"
FT                   /id="PRO_0000346132"
FT   MOD_RES         45
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   92 AA;  10157 MW;  A80CCD5A35C33B58 CRC64;
     LKMGAMFVLL LLFTLASSQQ EGDVQARKTS LKSDFYRALR QYDRQCTLVN NCDRNGERAC
     NGDCSCEGQI CKCGYRVSPG KSGCACTCRN AK