ID   CS82_CONCB              Reviewed;          90 AA.
AC   B1PZN6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Conotoxin Ca8.2 {ECO:0000303|PubMed:18423793};
DE   AltName: Full=Ca-84 {ECO:0000303|PubMed:30917600};
DE   Flags: Precursor;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=18423793; DOI=10.1016/j.toxicon.2008.03.001;
RA   Liu L., Wu X., Yuan D., Chi C., Wang C.;
RT   "Identification of a novel S-superfamily conotoxin from vermivorous Conus
RT   caracteristicus.";
RL   Toxicon 51:1331-1337(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=30917600; DOI=10.3390/md17030193;
RA   Yao G., Peng C., Zhu Y., Fan C., Jiang H., Chen J., Cao Y., Shi Q.;
RT   "High-throughput identification and analysis of novel conotoxins from three
RT   vermivorous cone snails by transcriptome sequencing.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is VIII (C-C-C-C-C-C-C-C-C-C).
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin S superfamily. {ECO:0000305}.
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DR   EMBL; EU516350; ACB05658.1; -; mRNA.
DR   AlphaFoldDB; B1PZN6; -.
DR   ConoServer; 2823; Ca8b precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..46
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000346135"
FT   PEPTIDE         47..89
FT                   /note="Conotoxin Ca8.2"
FT                   /id="PRO_0000346136"
FT   MOD_RES         89
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   90 AA;  9988 MW;  7E6BEE69C2B53111 CRC64;
     MMLKMGAMFV LLLLFILPSS QQEGDVQARK THLKRGFYGT LAMSTRGCSG TCHRREDGKC
     RGTCDCSGYS YCRCGDAHHF YRGCTCSCQG