ID   CS8A_CONCB              Reviewed;          88 AA.
AC   B0L0Y5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Conotoxin Ca8a {ECO:0000303|PubMed:18423793};
DE   AltName: Full=Conotoxin Ca8.1 {ECO:0000303|PubMed:18423793};
DE   Flags: Precursor;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-88, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=18423793; DOI=10.1016/j.toxicon.2008.03.001;
RA   Liu L., Wu X., Yuan D., Chi C., Wang C.;
RT   "Identification of a novel S-superfamily conotoxin from vermivorous Conus
RT   caracteristicus.";
RL   Toxicon 51:1331-1337(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is VIII (C-C-C-C-C-C-C-C-C-C).
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=4606.3; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:18423793};
CC   -!- SIMILARITY: Belongs to the conotoxin S superfamily. {ECO:0000305}.
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DR   EMBL; EF208032; ABQ00572.2; -; mRNA.
DR   AlphaFoldDB; B0L0Y5; -.
DR   PRIDE; B0L0Y5; -.
DR   ConoServer; 2824; Ca8a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..46
FT                   /evidence="ECO:0000269|PubMed:18423793"
FT                   /id="PRO_0000346133"
FT   PEPTIDE         47..88
FT                   /note="Conotoxin Ca8a"
FT                   /evidence="ECO:0000269|PubMed:18423793"
FT                   /id="PRO_0000346134"
SQ   SEQUENCE   88 AA;  9816 MW;  0E6DD2B5311118EB CRC64;
     MMLKMGAMFV LLLLFILPSS QQEGDVQARK THLKRGFYGT LAMSTRGCSG TCHRREDGKC
     RGTCDCSGYS YCRCGDAHHF YRGCTCTC