ID   CSA3_METJA              Reviewed;         208 AA.
AC   Q57824;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=CRISPR locus-related putative DNA-binding protein Csa3;
GN   Name=csa3; OrderedLocusNames=MJ0379;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated Csa3 family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB98369.1; -; Genomic_DNA.
DR   PIR; C64347; C64347.
DR   AlphaFoldDB; Q57824; -.
DR   SMR; Q57824; -.
DR   STRING; 243232.MJ_0379; -.
DR   EnsemblBacteria; AAB98369; AAB98369; MJ_0379.
DR   KEGG; mja:MJ_0379; -.
DR   eggNOG; arCOG01446; Archaea.
DR   HOGENOM; CLU_1248328_0_0_2; -.
DR   InParanoid; Q57824; -.
DR   OMA; GEHINHI; -.
DR   PhylomeDB; Q57824; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010163; Csa3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01884; cas_HTH; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; DNA-binding; Reference proteome.
FT   CHAIN           1..208
FT                   /note="CRISPR locus-related putative DNA-binding protein
FT                   Csa3"
FT                   /id="PRO_0000106842"
SQ   SEQUENCE   208 AA;  24080 MW;  163D155C47FA2623 CRC64;
     MVRYMRYIAT FGYHTNHIFD KNGKIIGIDD EKISNMILIY SLDVDADENT VNSIKNTKNY
     IESKLKEYNI PYLFVEVNPY EFNTNVKNFR KYIVPKTIIN LTGGKRIVGY ALFYAAVLEK
     ENVEKVFYVS KLGDIIEFPL IPPDIKLTEL EMKILNLLDK EGEMSVSNIA HKLERSLSTI
     SEYVSQLEKK GLVKKLSKGR RKIVKKVI