ID   CSA3_THETK              Reviewed;         204 AA.
AC   G4RJY9;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=CRISPR locus-related putative DNA-binding protein Csa3;
GN   Name=csa3; OrderedLocusNames=TTX_1249;
OS   Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS   / Kra 1).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Thermoproteus.
OX   NCBI_TaxID=768679;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX   PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA   Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA   Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA   Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA   Hensel R.;
RT   "The complete genome sequence of Thermoproteus tenax: a physiologically
RT   versatile member of the Crenarchaeota.";
RL   PLoS ONE 6:E24222-E24222(2011).
RN   [2]
RP   INDUCTION, AND OPERON STRUCTURE.
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX   PubMed=22408157; DOI=10.1128/jb.00206-12;
RA   Plagens A., Tjaden B., Hagemann A., Randau L., Hensel R.;
RT   "Characterization of the CRISPR/Cas subtype I-A system of the
RT   hyperthermophilic crenarchaeon Thermoproteus tenax.";
RL   J. Bacteriol. 194:2491-2500(2012).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). A putative DNA-binding protein it may regulate either or
CC       both of the Cas protein operons encoded on either side of it.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Not significantly induced by ultraviolet light or by NaCl. A
CC       monocistronic operon. {ECO:0000269|PubMed:22408157}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated Csa3 family.
CC       {ECO:0000305}.
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DR   EMBL; FN869859; CCC81884.1; -; Genomic_DNA.
DR   RefSeq; WP_014127139.1; NC_016070.1.
DR   AlphaFoldDB; G4RJY9; -.
DR   SMR; G4RJY9; -.
DR   STRING; 768679.TTX_1249; -.
DR   EnsemblBacteria; CCC81884; CCC81884; TTX_1249.
DR   GeneID; 11262129; -.
DR   KEGG; ttn:TTX_1249; -.
DR   PATRIC; fig|768679.9.peg.1262; -.
DR   eggNOG; arCOG01451; Archaea.
DR   HOGENOM; CLU_1292074_0_0_2; -.
DR   OMA; FEHRFAV; -.
DR   Proteomes; UP000002654; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010163; Csa3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01884; cas_HTH; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; DNA-binding; Reference proteome.
FT   CHAIN           1..204
FT                   /note="CRISPR locus-related putative DNA-binding protein
FT                   Csa3"
FT                   /id="PRO_0000422233"
SQ   SEQUENCE   204 AA;  22202 MW;  02E9AA02EF4255D5 CRC64;
     MRMGITVGFE HRFAVRALAK LGPADEYIFL YAYTGRDEDS RSESTVRELI AAFGRGAGFR
     VDLTKPSEAL EQIYGLGLER VVLAGGPRLL VLLALLASLL RRSEVYVLPE YSAEPLDLTP
     LTALCDLCRL SPAKLGIVAS VSGRVGIDDV AQLVGRDSTT VARYLKDLSE AGIVKSLGGR
     RREYFVDPLL TTVARLMQNR AGSL