ID   CSA5_THETK              Reviewed;         130 AA.
AC   G4RJZ0;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=CRISPR system associated protein Csa5;
GN   Name=csa5; OrderedLocusNames=TTX_1250;
OS   Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS   / Kra 1).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Thermoproteus.
OX   NCBI_TaxID=768679;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX   PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA   Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA   Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA   Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA   Hensel R.;
RT   "The complete genome sequence of Thermoproteus tenax: a physiologically
RT   versatile member of the Crenarchaeota.";
RL   PLoS ONE 6:E24222-E24222(2011).
RN   [2]
RP   SUBUNIT, INDUCTION, AND OPERON STRUCTURE.
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX   PubMed=22408157; DOI=10.1128/jb.00206-12;
RA   Plagens A., Tjaden B., Hagemann A., Randau L., Hensel R.;
RT   "Characterization of the CRISPR/Cas subtype I-A system of the
RT   hyperthermophilic crenarchaeon Thermoproteus tenax.";
RL   J. Bacteriol. 194:2491-2500(2012).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Can form a Cascade complex with Cas7, Cas5a, Cas3, Cas3' and
CC       Cas8a2. {ECO:0000269|PubMed:22408157}.
CC   -!- INDUCTION: Repressed by 5 J/m2 ultraviolet light and 50 mM NaCl,
CC       slightly induced by 20 J/m2 ultraviolet light, 100 and 150 mM Nacl.
CC       Member of the csa5-cas7-cas5a-cas3-cas3'-cas8a2 operon.
CC       {ECO:0000269|PubMed:22408157}.
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DR   EMBL; FN869859; CCC81885.1; -; Genomic_DNA.
DR   RefSeq; WP_014127140.1; NC_016070.1.
DR   AlphaFoldDB; G4RJZ0; -.
DR   SMR; G4RJZ0; -.
DR   STRING; 768679.TTX_1250; -.
DR   EnsemblBacteria; CCC81885; CCC81885; TTX_1250.
DR   GeneID; 11262130; -.
DR   KEGG; ttn:TTX_1250; -.
DR   PATRIC; fig|768679.9.peg.1263; -.
DR   eggNOG; arCOG04193; Archaea.
DR   HOGENOM; CLU_1901838_0_0_2; -.
DR   OMA; RLFCAMA; -.
DR   Proteomes; UP000002654; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..130
FT                   /note="CRISPR system associated protein Csa5"
FT                   /id="PRO_0000422234"
SQ   SEQUENCE   130 AA;  15036 MW;  58F1377D2223E7CD CRC64;
     MESVQLKKEE LVERAARSVR PAVHLEMAYD VLDELSRSPE KYPEQLAKLS RIVVKVLNDV
     EDELEHNPQN EELQKARNRL AAWGGYVAEL AKRLEEADDR ERIRMVRLFC AMALAPDKLT
     VELKKLLKGR