CSAG2_HUMAN
ID CSAG2_HUMAN Reviewed; 127 AA.
AC Q9Y5P2; O75605; Q0VDC3; Q96IU8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Chondrosarcoma-associated gene 2/3 protein;
DE AltName: Full=Cancer/testis antigen 24.2;
DE Short=CT24.2;
DE AltName: Full=Taxol-resistant-associated gene 3 protein;
DE Short=TRAG-3;
GN Name=CSAG2; Synonyms=TRAG3;
GN and
GN Name=CSAG3; Synonyms=CSAG3A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Ovary;
RX PubMed=10095106; DOI=10.1016/s0378-1119(99)00042-6;
RA Duan Z., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.;
RT "TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma
RT cell line.";
RL Gene 229:75-81(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Ovary;
RA Duan Z., Aynn F., Toh H.C., Seiden M.V.;
RT "Identification a novel TRAG-3 variant gene, TRAG-3L, from a taxol-
RT resistant ovarian cancer cell line SKOV-3.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Drug-resistance related protein, its expression is associated
CC with the chemotherapy resistant and neoplastic phenotype. May also be
CC linked to the malignant phenotype.
CC -!- INTERACTION:
CC Q9Y5P2; Q96EB6: SIRT1; NbExp=8; IntAct=EBI-26354757, EBI-1802965;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=Long, TRAG-3L;
CC IsoId=Q9Y5P2-1; Sequence=Displayed;
CC Name=2; Synonyms=Short, TRAG-3S;
CC IsoId=Q9Y5P2-2; Sequence=VSP_004469;
CC Name=3;
CC IsoId=Q9Y5P2-3; Sequence=VSP_034912, VSP_034913;
CC -!- TISSUE SPECIFICITY: Weakly expressed in kidney. Expressed in various
CC tumor cell lines including carcinomas, myeloid and lymphoid
CC malignancies, melanomas and prostate cancer. Overexpressed in taxol-
CC resistant breast cancer line MDA 435TR and the doxorubicin-resistant
CC multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.
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DR EMBL; AF080246; AAC29487.1; -; mRNA.
DR EMBL; AF136715; AAD37859.1; -; mRNA.
DR EMBL; CH471169; EAW99428.1; -; Genomic_DNA.
DR EMBL; BC007228; AAH07228.1; -; mRNA.
DR EMBL; BC119734; AAI19735.1; -; mRNA.
DR EMBL; BC119735; AAI19736.1; -; mRNA.
DR RefSeq; NP_001123298.1; NM_001129826.2. [Q9Y5P2-1]
DR RefSeq; NP_001123300.1; NM_001129828.2. [Q9Y5P2-2]
DR AlphaFoldDB; Q9Y5P2; -.
DR SMR; Q9Y5P2; -.
DR BioGRID; 133321; 1.
DR IntAct; Q9Y5P2; 95.
DR MINT; Q9Y5P2; -.
DR iPTMnet; Q9Y5P2; -.
DR PhosphoSitePlus; Q9Y5P2; -.
DR BioMuta; CSAG2; -.
DR PRIDE; Q9Y5P2; -.
DR Antibodypedia; 80508; 3 antibodies from 2 providers.
DR DNASU; 389903; -.
DR Ensembl; ENST00000599845.3; ENSP00000491011.1; ENSG00000268916.6. [Q9Y5P2-1]
DR Ensembl; ENST00000638835.1; ENSP00000492276.1; ENSG00000268916.6. [Q9Y5P2-2]
DR GeneID; 389903; -.
DR KEGG; hsa:389903; -.
DR CTD; 389903; -.
DR DisGeNET; 389903; -.
DR GeneCards; CSAG2; -.
DR GeneCards; CSAG3; -.
DR HGNC; HGNC:16847; CSAG2.
DR HGNC; HGNC:26237; CSAG3.
DR HPA; ENSG00000268916; Tissue enhanced (lymphoid tissue, testis).
DR neXtProt; NX_Q9Y5P2; -.
DR OpenTargets; ENSG00000268916; -.
DR PharmGKB; PA134919230; -.
DR VEuPathDB; HostDB:ENSG00000268916; -.
DR GeneTree; ENSGT00390000012766; -.
DR InParanoid; Q9Y5P2; -.
DR OMA; WCEFLAC; -.
DR OrthoDB; 1407896at2759; -.
DR PhylomeDB; Q9Y5P2; -.
DR PathwayCommons; Q9Y5P2; -.
DR SignaLink; Q9Y5P2; -.
DR SIGNOR; Q9Y5P2; -.
DR BioGRID-ORCS; 389903; 2 hits in 129 CRISPR screens.
DR GenomeRNAi; 389903; -.
DR Pharos; Q9Y5P2; Tdark.
DR PRO; PR:Q9Y5P2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9Y5P2; protein.
DR Bgee; ENSG00000268916; Expressed in left testis and 70 other tissues.
DR GO; GO:0009410; P:response to xenobiotic stimulus; TAS:ProtInc.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..127
FT /note="Chondrosarcoma-associated gene 2/3 protein"
FT /id="PRO_0000079390"
FT REGION 68..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..67
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034912"
FT VAR_SEQ 89..105
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_004469"
FT VAR_SEQ 94..105
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034913"
FT CONFLICT 33
FT /note="R -> H (in Ref. 1; AAC29487 and 2; AAD37859)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="L -> H (in Ref. 1; AAC29487 and 2; AAD37859)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="R -> I (in Ref. 1; AAC29487 and 2; AAD37859)"
FT /evidence="ECO:0000305"
FT CONFLICT 110
FT /note="P -> L (in Ref. 1; AAC29487 and 2; AAD37859)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="K -> E (in Ref. 1; AAC29487 and 2; AAD37859)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 127 AA; 14430 MW; EC1B2C1758129BCC CRC64;
MWMGLIQLVE GVKRKDQGFL EKEFYHKTNI KMRCEFLACW PAFTVLGEAW RDQVDWSRLL
RDAGLVKMSR KPRASSPLSN NHPPTPKRRG SGRHPLNPGP EALSKFPRQP GREKGPIKEV
PGTKGSP
