CSBC_BACSU
ID CSBC_BACSU Reviewed; 461 AA.
AC P46333; O32289;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 04-AUG-2003, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable metabolite transport protein CsbC;
GN Name=csbC; Synonyms=yxcC; OrderedLocusNames=BSU39810; ORFNames=SS92BR;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=7584049; DOI=10.1093/dnares/2.2.61;
RA Yoshida K., Seki S., Fujimura M., Miwa Y., Fujita Y.;
RT "Cloning and sequencing of a 36-kb region of the Bacillus subtilis genome
RT between the gnt and iol operons.";
RL DNA Res. 2:61-69(1995).
RN [2]
RP SEQUENCE REVISION.
RA Fujita Y., Shibayama T., Ishio I., Aoyama D., Yoshida K.;
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP CHARACTERIZATION.
RX PubMed=10376822; DOI=10.1099/13500872-145-5-1069;
RA Akbar S., Lee S.Y., Boylan S.A., Price C.W.;
RT "Two genes from Bacillus subtilis under the sole control of the general
RT stress transcription factor sigmaB.";
RL Microbiology 145:1069-1078(1999).
CC -!- FUNCTION: Could serve either a nutritional or an osmotic protection
CC function.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AB005554; BAA21604.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB16017.1; -; Genomic_DNA.
DR PIR; D70073; D70073.
DR RefSeq; NP_391860.1; NC_000964.3.
DR RefSeq; WP_003244055.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P46333; -.
DR SMR; P46333; -.
DR IntAct; P46333; 12.
DR STRING; 224308.BSU39810; -.
DR TCDB; 2.A.1.1.106; the major facilitator superfamily (mfs).
DR PaxDb; P46333; -.
DR PRIDE; P46333; -.
DR EnsemblBacteria; CAB16017; CAB16017; BSU_39810.
DR GeneID; 937639; -.
DR KEGG; bsu:BSU39810; -.
DR PATRIC; fig|224308.179.peg.4307; -.
DR eggNOG; COG2814; Bacteria.
DR InParanoid; P46333; -.
DR OMA; VAQFLCM; -.
DR PhylomeDB; P46333; -.
DR BioCyc; BSUB:BSU39810-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..461
FT /note="Probable metabolite transport protein CsbC"
FT /id="PRO_0000050303"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..341
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 400..401
FT /note="SA -> RP (in Ref. 1; BAA21604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 461 AA; 50140 MW; AD59CB5DD6372FE0 CRC64;
MKKDTRKYMI YFFGALGGLL YGYDTGVISG ALLFINNDIP LTTLTEGLVV SMLLLGAIFG
SALSGTCSDR WGRRKVVFVL SIIFIIGALA CAFSQTIGML IASRVILGLA VGGSTALVPV
YLSEMAPTKI RGTLGTMNNL MIVTGILLAY IVNYLFTPFE AWRWMVGLAA VPAVLLLIGI
AFMPESPRWL VKRGSEEEAR RIMNITHDPK DIEMELAEMK QGEAEKKETT LGVLKAKWIR
PMLLIGVGLA IFQQAVGINT VIYYAPTIFT KAGLGTSASA LGTMGIGILN VIMCITAMIL
IDRVGRKKLL IWGSVGITLS LAALSGVLLT LGLSASTAWM TVVFLGVYIV FYQATWGPVV
WVLMPELFPS KARGAATGFT TLVLSAANLI VSLVFPLMLS AMGIAWVFMV FSVICLLSFF
FAFYMVPETK GKSLEEIEAS LKKRFKKKKS TQNQVLNERT L
