CSBX_BACSU
ID CSBX_BACSU Reviewed; 435 AA.
AC O05390; O32056;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 3.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Alpha-ketoglutarate permease;
GN Name=csbX; OrderedLocusNames=BSU27760;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / PY79;
RX PubMed=9025289; DOI=10.1099/00221287-143-1-157;
RA Gomez M., Cutting S.M.;
RT "BofC encodes a putative forespore regulator of the Bacillus subtilis sigma
RT K checkpoint.";
RL Microbiology 143:157-170(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Tosato V., Bolotin A., Bertani I., Valentino I., Bruschi C.V.;
RT "A 17.8 kb segment in the spoVB-nadC region of the Bacillus subtilis 168
RT chromosome: sequencing and ruv operon identification.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 364.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [5]
RP CHARACTERIZATION OF EXPRESSION.
RX PubMed=9099855; DOI=10.1016/s0378-1119(96)00770-6;
RA Gomez M., Cutting S.M.;
RT "Identification of a new sigmaB-controlled gene, csbX, in Bacillus
RT subtilis.";
RL Gene 188:29-33(1997).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the stationary phase of cell
CC growth.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. CsbX subfamily. {ECO:0000305}.
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DR EMBL; X93081; CAA63620.1; -; Genomic_DNA.
DR EMBL; Y15896; CAB75328.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14736.2; -; Genomic_DNA.
DR PIR; H69607; H69607.
DR RefSeq; NP_390654.2; NC_000964.3.
DR RefSeq; WP_003246197.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O05390; -.
DR SMR; O05390; -.
DR STRING; 224308.BSU27760; -.
DR TCDB; 2.A.1.18.3; the major facilitator superfamily (mfs).
DR PaxDb; O05390; -.
DR PRIDE; O05390; -.
DR EnsemblBacteria; CAB14736; CAB14736; BSU_27760.
DR GeneID; 937527; -.
DR KEGG; bsu:BSU27760; -.
DR PATRIC; fig|224308.179.peg.3016; -.
DR eggNOG; COG2814; Bacteria.
DR OMA; GWRNTVM; -.
DR PhylomeDB; O05390; -.
DR BioCyc; BSUB:BSU27760-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004748; Polyol_permease.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00897; 2A0118; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..435
FT /note="Alpha-ketoglutarate permease"
FT /id="PRO_0000050494"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..320
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..354
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..435
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 78
FT /note="Q -> E (in Ref. 1; CAA63620)"
FT /evidence="ECO:0000305"
FT CONFLICT 290
FT /note="G -> A (in Ref. 1; CAA63620)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="Missing (in Ref. 1; CAA63620)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="S -> F (in Ref. 2; CAB75328)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 435 AA; 47803 MW; 118B0A80EF01940B CRC64;
MNTVHAKGNV LNKIGIPSHM VWGYIGVVIF MVGDGLEQGW LSPFLVDHGL SMQQSASLFT
MYGIAVTISA WLSGTFVQTW GPRKTMTVGL LAFILGSAAF IGWAIPHMYY PALLGSYALR
GLGYPLFAYS FLVWVSYSTS QNILGKAVGW FWFMFTCGLN VLGPFYSSYA VPAFGEINTL
WSALLFVAAG GILALFFNKD KFTPIQKQDQ PKWKELSKAF TIMFENPKVG IGGVVKTINA
IGQFGFAIFL PTYLARYGYS VSEWLQIWGT LFFVNIVFNI IFGAVGDKLG WRNTVMWFGG
VGCGIFTLAL YYTPQLIGHQ YWVLMIIACC YGAALAGYVP LSALLPTLAP DNKGAAMSVL
NLGSGLCAFI APGIVSLFIG PLGAGGVIWI FAALYFFSAF LTRFLTISEQ STDVYTEERF
VRENVQTNFD KTVKQ
