ID   CSCL1_PONAB             Reviewed;         807 AA.
AC   Q5R826;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=CSC1-like protein 1;
DE   AltName: Full=Transmembrane protein 63A;
GN   Name=TMEM63A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel (By
CC       similarity). Mechanosensitive ion channel that converts mechanical
CC       stimuli into a flow of ion (By similarity).
CC       {ECO:0000250|UniProtKB:Q91YT8}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O94886};
CC       Multi-pass membrane protein {ECO:0000255}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q91YT8}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
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DR   EMBL; CR859929; CAH92084.1; -; mRNA.
DR   RefSeq; NP_001126216.1; NM_001132744.1.
DR   AlphaFoldDB; Q5R826; -.
DR   SMR; Q5R826; -.
DR   STRING; 9601.ENSPPYP00000024509; -.
DR   GeneID; 100173184; -.
DR   KEGG; pon:100173184; -.
DR   CTD; 9725; -.
DR   eggNOG; KOG1134; Eukaryota.
DR   InParanoid; Q5R826; -.
DR   OrthoDB; 395194at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:1990760; F:osmolarity-sensing cation channel activity; ISS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR032880; Csc1_N.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR027815; PHM7_cyt.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR003864; RSN1_7TM.
DR   InterPro; IPR026957; TMEM63A.
DR   PANTHER; PTHR13018; PTHR13018; 1.
DR   PANTHER; PTHR13018:SF24; PTHR13018:SF24; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Ion channel; Ion transport; Lysosome; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..807
FT                   /note="CSC1-like protein 1"
FT                   /id="PRO_0000280727"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        553..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        620..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        665..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        698..718
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         739
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91YT8"
SQ   SEQUENCE   807 AA;  92255 MW;  D415CBC95C35A72A CRC64;
     MTDSPFLELW QSRAVSVREQ LGLGDRPNDS YCYNSAKNST VLQGVTFGGI PTVLLIDVSC
     FLFLILVFSI IRRRFWDYGR IALVSEADSE PRFQRLSSTS SSGQQDFENE LGCCPWLTAI
     FRLHDDQILE WCGEDAIHYL SFQRHIIFLL VVVSFLSLCV ILPVNLSGDL LDKDPYSFGR
     TTIANLQTDN DLLWLHTIFA VIYLFLTVGF MRHHTQSIKY KEENLVRRTL FITGLPRDAR
     KETVESHFRD AYPTCEVVDV QLCYNVAKLI YLCKERKKTE KSLTYYTNLQ VKTGQRTLIN
     PKPCGQFCCC EVQGCEWEDA ISYYTRMKDR LLERITEEER HVQDQPLGMA FVTFQEKSMA
     TYILKDFNAC KCQSLQCKGE PQPSSHSREL YTSKWTVTFA ADPEDICWKN LSIQGLRWWL
     QWLGINFTLF LGLFFLTTPS IILSTMDKFN VTKPIHALNN PIISQFFPTL LLWSFSALLP
     SIVYYSTLLE SHWTKSGENQ IMMTKVYIFL IFMVLILPSL GLTSLDFFFR WLFDKTSSEA
     SIRLECVFLP DQGAFFVNYV IASAFIGNGM ELLRLPGLIL YTFRMIMAKT AADRRNVKQN
     QAFQYEFGAM YAWMLCVFTV IMAYSITCPI IAPFGLIYIL LKHMVDRHNL YFIYLPAKLE
     KGIHFAAVNQ ALAAPILCLF WLYFFSFLRL GMKAPATLFT FLVVLLTILV CLAHTCFGYF
     KHLSPLNYKT EEPASDKGSE AEAHMPPPFT PYVPRILNGL ASERTALSPQ QQQQQTYGAI
     HNISGTIPGQ CLAQSATGSV AAAPQEA