CSCL4_ARATH
ID CSCL4_ARATH Reviewed; 756 AA.
AC Q9LVE4; Q56ZM5;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=CSC1-like protein At3g21620;
GN OrderedLocusNames=At3g21620; ORFNames=MIL23.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=24503647; DOI=10.1038/cr.2014.14;
RA Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA Li L.;
RT "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT channels conserved across eukaryotes.";
RL Cell Res. 24:632-635(2014).
CC -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
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DR EMBL; AB019232; BAB02357.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76531.1; -; Genomic_DNA.
DR EMBL; AK220939; BAD94445.1; -; mRNA.
DR RefSeq; NP_188799.1; NM_113057.3.
DR AlphaFoldDB; Q9LVE4; -.
DR SMR; Q9LVE4; -.
DR STRING; 3702.AT3G21620.1; -.
DR iPTMnet; Q9LVE4; -.
DR PaxDb; Q9LVE4; -.
DR PRIDE; Q9LVE4; -.
DR ProteomicsDB; 224554; -.
DR EnsemblPlants; AT3G21620.1; AT3G21620.1; AT3G21620.
DR GeneID; 821716; -.
DR Gramene; AT3G21620.1; AT3G21620.1; AT3G21620.
DR KEGG; ath:AT3G21620; -.
DR Araport; AT3G21620; -.
DR TAIR; locus:2089850; AT3G21620.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_7_1_1; -.
DR InParanoid; Q9LVE4; -.
DR OMA; QAYRYNL; -.
DR OrthoDB; 395194at2759; -.
DR PhylomeDB; Q9LVE4; -.
DR PRO; PR:Q9LVE4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LVE4; baseline and differential.
DR Genevisible; Q9LVE4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR032880; Csc1_N.
DR InterPro; IPR027815; PHM7_cyt.
DR InterPro; IPR003864; RSN1_7TM.
DR PANTHER; PTHR13018; PTHR13018; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 2: Evidence at transcript level;
KW Calcium; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..756
FT /note="CSC1-like protein At3g21620"
FT /id="PRO_0000429802"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 731..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 18
FT /note="A -> V (in Ref. 3; BAD94445)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 756 AA; 86687 MW; C54D9E4A60664BAC CRC64;
MATLTDIGVA ATINILTAFA FFIAFAILRL QPVNDRVYFP KWYLKGLRSS PIKTGGFASK
FVNLDFRSYI RFLNWMPQAL RMPEPELIDH AGLDSVVYLR IYLLGLKIFF PIACIAFTVM
VPVNWTNSTL DQLKNLTFSD IDKLSISNIP TGSSRFWVHL CMAYVITFWT CFVLQREYKH
IASMRLQFLA SEHRRPDQFT VLVRNIPPDP DESVSELVEH FFKVNHPDYY LTYQAVYNAN
KLSELVQKRM KLQNWLDYYQ NKHSRNPSKR PLIKIGFLGC WGEEVDAIDH YIEKIEGLTR
KISEEKETVM SSTKSLVPAA FVSFKKRWGA VVCSQTQQSR NPTEWLTEWA PEPRDIYWDN
LALPYVQLTI RRLVIAVAFF FLTFFFMIPI AFVQTLANIE GIEKAVPFLK PLIEVKTVKS
FIQGFLPGIA LKIFLIVLPS ILMLMSKFEG FISKSSLERR CASRYYMFQF INVFLCSIIA
GTALQQLDSF LNQSATEIPK TIGVSIPMKA TFFITYIMVD GWAGVAGEIL RLKPLIIYHL
KNFFLVKTEK DREEAMDPGT IGFNTGEPQI QLYFILGLVY AAVSPILLPF ILVFFALAYV
VYRHQIINVY NQEYESAAAF WPDVHRRVVI ALIVSQLLLM GLLSTKKAAR STPLLFILPV
LTIGFHKFCQ GRYQPIFVTY PLQDAMVKDT LERMREPNLN LKTFLQNAYA HPVFKAADNL
ANEMVVEEPA PDKTPDLVAT KRGSRRFNSG SAETFT
