ID   CSCL6_ARATH             Reviewed;         778 AA.
AC   F4HYR3; Q9MAV5;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=CSC1-like protein At1g62320;
GN   OrderedLocusNames=At1g62320; ORFNames=F24O1.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=24503647; DOI=10.1038/cr.2014.14;
RA   Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA   Li L.;
RT   "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT   channels conserved across eukaryotes.";
RL   Cell Res. 24:632-635(2014).
CC   -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE33953.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC003113; AAF70851.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE33953.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; ANM61021.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM61023.1; -; Genomic_DNA.
DR   PIR; H96649; H96649.
DR   PIR; T01441; T01441.
DR   RefSeq; NP_001319293.1; NM_001334028.1.
DR   RefSeq; NP_001323266.1; NM_001334030.1.
DR   RefSeq; NP_001323268.1; NM_001334032.1.
DR   AlphaFoldDB; F4HYR3; -.
DR   SMR; F4HYR3; -.
DR   BioGRID; 27751; 2.
DR   IntAct; F4HYR3; 2.
DR   STRING; 3702.AT1G62320.1; -.
DR   PaxDb; F4HYR3; -.
DR   PRIDE; F4HYR3; -.
DR   ProteomicsDB; 220349; -.
DR   EnsemblPlants; AT1G62320.3; AT1G62320.3; AT1G62320.
DR   EnsemblPlants; AT1G62320.5; AT1G62320.5; AT1G62320.
DR   GeneID; 842530; -.
DR   Gramene; AT1G62320.3; AT1G62320.3; AT1G62320.
DR   Gramene; AT1G62320.5; AT1G62320.5; AT1G62320.
DR   KEGG; ath:AT1G62320; -.
DR   Araport; AT1G62320; -.
DR   TAIR; locus:2027119; AT1G62320.
DR   eggNOG; KOG1134; Eukaryota.
DR   InParanoid; F4HYR3; -.
DR   OMA; YYKYALK; -.
DR   OrthoDB; 186546at2759; -.
DR   PhylomeDB; F4HYR3; -.
DR   PRO; PR:F4HYR3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HYR3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR032880; Csc1_N.
DR   InterPro; IPR027815; PHM7_cyt.
DR   InterPro; IPR003864; RSN1_7TM.
DR   PANTHER; PTHR13018; PTHR13018; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Calcium; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..778
FT                   /note="CSC1-like protein At1g62320"
FT                   /id="PRO_0000429804"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        584..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        626..646
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        651..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          738..778
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..769
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   778 AA;  89309 MW;  52533674565B3E95 CRC64;
     MATLADIGLA AAINILSALI FLLLFAILRI QPFNDRVYFP KWYLKGVRSS PVNSGAFVSK
     IMNLDFRSYV RFLNWMPDAL KMPEPELIDH AGLDSAVYLR IYLIGLKIFG PIALLSWSIL
     VPVNWTSDGL QLAKLRNVTS SNIDKLSISN VERGSDRFWA HLVMAYAFTF WTCYVLMKEY
     EKIAAMRLSF LQSEKRRADQ FTVLVRNVPP DSDESISENV QHFFLVNHPD HYLTHQVVYN
     ANELAKLVED KKKMQNWLDY YQLKYTRNKE QRPRVKMGFL GLWGKKVDAM DHYTAEIEKL
     SEQIMEERKR IKKDDKSVMQ AAFVSFKTRW GAAVCAQTQQ TKNPTEWLTE WAPEAREMYW
     PNLAMPYVSL TVRRFVMHIA FFFLTFFFII PIAFVQSLAS IEGIEKSAPF LSPIVKNKLM
     KSLIQGFLPG IVLKLFLIFL PTILMIMSKF EGFISISSLE RRAAFRYYIF NLVNVFLGSV
     ITGSAFEQLD SFLKQSANDI PRTVGVAIPI KATFFITYIM VDGWAGVAGE IFRLKPLVIF
     HLKNFFFVKT EKDREEAMDP GQIDFYATEP RIQLYFLLGL VYAPVTPVLL PFIIFFFGFA
     YLVFRHQIIN VYNQKYESAG AFWPDVHGRI ISALIISQIL LLGLMSTKGK VQSTPFLLVL
     AILTFGFHRF CKGRYESAFV INPLQEAMIK DTLERAREPN LNLKGFLQNA YVHPVFKDEE
     DSDEEGLIED SDDEDCVVVQ TKRQRSRRTT VASSNASRGS SQSTPFNQLD LGKGKPET