ID   CSCL7_ARATH             Reviewed;         771 AA.
AC   B5TYT3; O65383;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=CSC1-like protein At1g11960;
GN   OrderedLocusNames=At1g11960; ORFNames=F12F1.17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia; TISSUE=Seedling;
RA   Tanaka K., Stacey G.;
RT   "Arabidopsis stress-inducible genes encoding membrane proteins.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=24503647; DOI=10.1038/cr.2014.14;
RA   Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA   Li L.;
RT   "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT   channels conserved across eukaryotes.";
RL   Cell Res. 24:632-635(2014).
CC   -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC17615.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; FJ041116; ACI01072.1; -; mRNA.
DR   EMBL; AC002131; AAC17615.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28821.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM58257.1; -; Genomic_DNA.
DR   PIR; E86254; E86254.
DR   RefSeq; NP_001320706.1; NM_001332015.1.
DR   RefSeq; NP_172660.5; NM_101068.6.
DR   AlphaFoldDB; B5TYT3; -.
DR   SMR; B5TYT3; -.
DR   STRING; 3702.AT1G11960.1; -.
DR   iPTMnet; B5TYT3; -.
DR   PaxDb; B5TYT3; -.
DR   PRIDE; B5TYT3; -.
DR   ProteomicsDB; 222770; -.
DR   EnsemblPlants; AT1G11960.1; AT1G11960.1; AT1G11960.
DR   EnsemblPlants; AT1G11960.3; AT1G11960.3; AT1G11960.
DR   GeneID; 837748; -.
DR   Gramene; AT1G11960.1; AT1G11960.1; AT1G11960.
DR   Gramene; AT1G11960.3; AT1G11960.3; AT1G11960.
DR   KEGG; ath:AT1G11960; -.
DR   Araport; AT1G11960; -.
DR   TAIR; locus:2008860; AT1G11960.
DR   eggNOG; KOG1134; Eukaryota.
DR   HOGENOM; CLU_002458_7_1_1; -.
DR   InParanoid; B5TYT3; -.
DR   OMA; NDYEDSR; -.
DR   OrthoDB; 395194at2759; -.
DR   PhylomeDB; B5TYT3; -.
DR   PRO; PR:B5TYT3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; B5TYT3; baseline and differential.
DR   Genevisible; B5TYT3; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IGI:TAIR.
DR   GO; GO:0140426; P:PAMP-triggered immunity signalling pathway; IGI:TAIR.
DR   GO; GO:0010118; P:stomatal movement; IMP:TAIR.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR032880; Csc1_N.
DR   InterPro; IPR027815; PHM7_cyt.
DR   InterPro; IPR003864; RSN1_7TM.
DR   PANTHER; PTHR13018; PTHR13018; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..771
FT                   /note="CSC1-like protein At1g11960"
FT                   /id="PRO_0000429805"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        584..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        630..650
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        651..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          744..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   771 AA;  88280 MW;  889182EC966964D6 CRC64;
     MATLGDIGVA AAINILTAII FLLAFAILRI QPFNDRVYFP KWYLKGIRSS PLHSGALVSK
     FVNVNLGSYL RFLNWMPAAL KMPEPELIDH AGLDSAVYLR IYLIGLKIFV PIALLAWSIL
     VPVNWTSHGL QLAKLRNVTS SDIDKLSISN IENGSDRFWT HLVMAYAFTF WTCYVLMKEY
     EKVAAMRLAF LQNEQRRPDQ FTVLVRNVPA DPDESISDSV EHFFLVNHPD HYLTHQVVYN
     ANDLAALVEQ KKSTQNWLDY YQLKYTRNQE HKPRIKTGFL GLWGKKVDAI DHYIAEIEKL
     NEQIMEERKK VKKDDTSVMP AAFVSFKTRW GAAVSAQTQQ SSDPTEWLTE WAPEAREVFW
     SNLAIPYVSL TVRRLIMHIA FFFLTFFFMI PIAFVQSLAS IEGIEKNAPF LKSIIENDLF
     KSVIQGFLPG IVLKLFLIFL PSILMVMSKF EGFVSLSSLE RRAAFRYYIF NLINVFLGSV
     ITGSAFEQLD SFLKQSAKEI PKTVGVAIPI KATFFITYIM VDGWAGIAGE ILRLKPLIFF
     HIKNSLLVKT EKDREEAMNP GQINYHATEP RIQLYFLLGL VYAPVTPVLL PFIIIFFALA
     YLVFRHQIIN VYNQEYESAA RFWPDVHGRI ISALIIAQIL LMGLLSTKGA AQSTPFLLFL
     PIITFFFHRY CKGRYEPAFL RHPLKEAMVK DTLERAREPN FNLKPYLQKA YIHPVFKDND
     YEDSRFDEIS GYCIEDSDEE CVTVPTKRQS RINTPAVSHA SRGSSRSPPS K