ID   CSCL8_ARATH             Reviewed;         712 AA.
AC   F4JCY2; Q9M1H6;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=CSC1-like protein At3g54510;
GN   OrderedLocusNames=At3g54510; ORFNames=T14E10_80;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=24503647; DOI=10.1038/cr.2014.14;
RA   Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA   Li L.;
RT   "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT   channels conserved across eukaryotes.";
RL   Cell Res. 24:632-635(2014).
CC   -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=F4JCY2-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB77571.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL138656; CAB77571.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE79244.1; -; Genomic_DNA.
DR   PIR; T47610; T47610.
DR   RefSeq; NP_001118837.1; NM_001125365.2. [F4JCY2-1]
DR   AlphaFoldDB; F4JCY2; -.
DR   SMR; F4JCY2; -.
DR   STRING; 3702.AT3G54510.2; -.
DR   iPTMnet; F4JCY2; -.
DR   PaxDb; F4JCY2; -.
DR   PRIDE; F4JCY2; -.
DR   ProteomicsDB; 222771; -. [F4JCY2-1]
DR   EnsemblPlants; AT3G54510.2; AT3G54510.2; AT3G54510. [F4JCY2-1]
DR   GeneID; 824616; -.
DR   Gramene; AT3G54510.2; AT3G54510.2; AT3G54510. [F4JCY2-1]
DR   KEGG; ath:AT3G54510; -.
DR   Araport; AT3G54510; -.
DR   TAIR; locus:2096991; AT3G54510.
DR   eggNOG; KOG1134; Eukaryota.
DR   HOGENOM; CLU_002458_7_1_1; -.
DR   InParanoid; F4JCY2; -.
DR   OMA; SAYKPPW; -.
DR   PRO; PR:F4JCY2; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; F4JCY2; baseline and differential.
DR   Genevisible; F4JCY2; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR032880; Csc1_N.
DR   InterPro; IPR027815; PHM7_cyt.
DR   InterPro; IPR003864; RSN1_7TM.
DR   PANTHER; PTHR13018; PTHR13018; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Calcium; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..712
FT                   /note="CSC1-like protein At3g54510"
FT                   /id="PRO_0000429806"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        546..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        597..617
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        623..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   712 AA;  81399 MW;  83E3EC2DC0D5B265 CRC64;
     MTPESLLASA SINIGLAVVA LWLFSVLKKQ PRNAVVYYAR RLSDRHHHRP LSLHSSLCLP
     RFLPSVAWIP RAFRVPEDEI LSRHGLDALV LIRLFKFGIR FFLMCSLLGA SLLLPVDYYN
     ESDLPTRREY SMDAFTISNI TRGSNKLWVH FSCLWCISFY ALFLLHKEYK EILVIRLQQM
     KELRHRADQF TVLVRQVPLC PEHNTRGCAV DHFFSKHHRF SYHSHQMLYD GRDLEYLLGK
     QKKLKKELED KRHTEILSNG SQEHKQISTS EEKLREITHM IYHLQSETML REKELPVAFV
     TFKSRRNAAL AAQTQQHSNP LELITEMAPE PRDVSWRNLA IPQKILPLNK IGVILAAALL
     TIFFAIPVTA VQGIAKYEKL KKWFPPAMAI EFIPGLSSVV TGYLPSAILK GFMYIIPFAM
     LGLAYLGGSI SNSKEEIKAC NMVFYFLMGN VFFLSLISGS LLDEIGEYLT HPRDIPSHLA
     AAVSAQAEFF MTYILTDGLS GFSLEILQLG LILFDIIRSY TYGRGKERTP YLFSFPYFRV
     IPTVSLSIMI GMIYAVVAPL MLPFLVGYFC LGYIVYFNQM EDVYETTYDT CGRFWPFIHH
     YIFVSIILMQ ITMVGLFGLK SKPSAAIATV PLILITIAYN EYCKIRFLPS FKHFPIQTAV
     EIDEEDEKNG EMETHYVDAA TAYNRHQPCL ERVSSAESPT NLSQPLLGTD SI