CSCL9_ARATH
ID CSCL9_ARATH Reviewed; 762 AA.
AC Q94A87; O80599; Q681Q0; Q8LC14;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=CSC1-like protein At1g10090;
GN OrderedLocusNames=At1g10090; ORFNames=T27I1.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [7]
RP GENE FAMILY.
RX PubMed=24503647; DOI=10.1038/cr.2014.14;
RA Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA Li L.;
RT "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT channels conserved across eukaryotes.";
RL Cell Res. 24:632-635(2014).
CC -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC34338.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004122; AAC34338.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28540.1; -; Genomic_DNA.
DR EMBL; AY049273; AAK83615.1; -; mRNA.
DR EMBL; AK175567; BAD43330.1; -; mRNA.
DR EMBL; AK176422; BAD44185.1; -; mRNA.
DR EMBL; AK176455; BAD44218.1; -; mRNA.
DR EMBL; AY086862; AAM63909.1; -; mRNA.
DR PIR; T00627; T00627.
DR RefSeq; NP_172480.2; NM_100883.3.
DR AlphaFoldDB; Q94A87; -.
DR SMR; Q94A87; -.
DR BioGRID; 22784; 4.
DR IntAct; Q94A87; 4.
DR STRING; 3702.AT1G10090.1; -.
DR iPTMnet; Q94A87; -.
DR PaxDb; Q94A87; -.
DR PRIDE; Q94A87; -.
DR ProteomicsDB; 220351; -.
DR EnsemblPlants; AT1G10090.1; AT1G10090.1; AT1G10090.
DR GeneID; 837544; -.
DR Gramene; AT1G10090.1; AT1G10090.1; AT1G10090.
DR KEGG; ath:AT1G10090; -.
DR Araport; AT1G10090; -.
DR TAIR; locus:2201876; AT1G10090.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_7_2_1; -.
DR InParanoid; Q94A87; -.
DR OMA; QTSNPME; -.
DR OrthoDB; 395194at2759; -.
DR PhylomeDB; Q94A87; -.
DR PRO; PR:Q94A87; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94A87; baseline and differential.
DR Genevisible; Q94A87; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR032880; Csc1_N.
DR InterPro; IPR027815; PHM7_cyt.
DR InterPro; IPR003864; RSN1_7TM.
DR PANTHER; PTHR13018; PTHR13018; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 1: Evidence at protein level;
KW Calcium; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..762
FT /note="CSC1-like protein At1g10090"
FT /id="PRO_0000429807"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 94
FT /note="S -> I (in Ref. 5; AAM63909)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="P -> L (in Ref. 4; BAD43330)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="R -> K (in Ref. 5; AAM63909)"
FT /evidence="ECO:0000305"
FT CONFLICT 471
FT /note="L -> F (in Ref. 5; AAM63909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 762 AA; 86768 MW; E1E37ED4D54F9642 CRC64;
MDVSALLTSA GINIAICVVL VSLYSILRKQ PANYCVYFGR LLSDGRVKRH DPRWYERFAP
SPSWLVKAWE TTEEEMLAAA GLDAVVFIRM VICSIRIFSI VAVVCLAFVL PVNYYGQKME
HKEVHLESLG VFTIENLNPR SRWLWVHCLS LYIISSAACA LLYFEYKNIA KKRLAHISGS
ASKPSHFTVL IRAIPQSPDQ SYSETVSKYF TNYYAPSYVS HLMVYRDGFI HRLMNETERM
CQAIKHVSPD LSCNPSLKSC VLCGPAATNS FQIISNETDS VKGLELGELT LTTTEEERPV
AFVFFKSRYD ALVVSEVLQT PNPMLWVADL APEPHDVHWR NLRIPYRQLW MRRIATLVGA
IAFMFVFLFP VTFVQGLTQL PTLSKNFPFL KDLLNRRFME QVITGYLPSV ILVLFFYTVP
PLMMYFSTLE GCVSRSQRKK SACLKILYFT IWNVFFVNIL SGSVIRQFTV LNSVRDVPAQ
LAKLVPAQAG FFMTYCFTSG WAGLACEIMQ PVGLIWNLIA KVIVKNKEES YETLRFPYHT
EIPRLLLFGL LGFTNSVIAP LILPFLLIYF FFAYLIYKNQ IINVYITKYE SGGQYWPVFH
NTTIFSLILS QVIALGFFGL KLSTVASGFT IPLILLTLLF SEYCRQRFAP IFQKYPAEIL
IAMDRADEMT GKMEEIHNNL KVAYSQIPTC SEESSKAGCT SPCSDQELPD SEELKPEKEN
LKADYIWEFQ RSKSGLDLEV KSCPSASPIR NSPGFAEIYK RT
