CSCLA_ARATH
ID CSCLA_ARATH Reviewed; 746 AA.
AC F4IBD7; F4IBD5; Q8W3K1; Q9SM00;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=CSC1-like protein RXW8;
GN Name=RXW8; OrderedLocusNames=At1g58520; ORFNames=R18I, X7J;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NUCLEOTIDE SEQUENCE [MRNA] OF 2-746.
RC STRAIN=cv. Columbia;
RX PubMed=10548732; DOI=10.1016/s0378-1119(99)00403-5;
RA Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
RT "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
RT genomic region located around the 100 map unit of chromosome 1.";
RL Gene 239:309-316(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=24503647; DOI=10.1038/cr.2014.14;
RA Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA Li L.;
RT "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT channels conserved across eukaryotes.";
RL Cell Res. 24:632-635(2014).
CC -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=F4IBD7-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA88270.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB83877.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAB84010.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB008023; BAA88270.1; ALT_INIT; mRNA.
DR EMBL; AB077822; BAB83877.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB078516; BAB84010.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33553.2; -; Genomic_DNA.
DR EMBL; CP002684; AEE33554.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59973.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59974.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59975.1; -; Genomic_DNA.
DR PIR; T52460; T52460.
DR RefSeq; NP_001319268.1; NM_001333840.1. [F4IBD7-1]
DR RefSeq; NP_001319269.1; NM_001333839.1. [F4IBD7-1]
DR RefSeq; NP_001322289.1; NM_001333843.1. [F4IBD7-1]
DR RefSeq; NP_001322290.1; NM_001333841.1. [F4IBD7-1]
DR RefSeq; NP_683440.2; NM_148599.4. [F4IBD7-1]
DR AlphaFoldDB; F4IBD7; -.
DR SMR; F4IBD7; -.
DR BioGRID; 27443; 8.
DR IntAct; F4IBD7; 6.
DR STRING; 3702.AT1G58520.2; -.
DR PaxDb; F4IBD7; -.
DR PRIDE; F4IBD7; -.
DR ProteomicsDB; 222772; -. [F4IBD7-1]
DR EnsemblPlants; AT1G58520.1; AT1G58520.1; AT1G58520. [F4IBD7-1]
DR EnsemblPlants; AT1G58520.2; AT1G58520.2; AT1G58520. [F4IBD7-1]
DR EnsemblPlants; AT1G58520.4; AT1G58520.4; AT1G58520. [F4IBD7-1]
DR EnsemblPlants; AT1G58520.6; AT1G58520.6; AT1G58520. [F4IBD7-1]
DR EnsemblPlants; AT1G58520.7; AT1G58520.7; AT1G58520. [F4IBD7-1]
DR GeneID; 842218; -.
DR Gramene; AT1G58520.1; AT1G58520.1; AT1G58520. [F4IBD7-1]
DR Gramene; AT1G58520.2; AT1G58520.2; AT1G58520. [F4IBD7-1]
DR Gramene; AT1G58520.4; AT1G58520.4; AT1G58520. [F4IBD7-1]
DR Gramene; AT1G58520.6; AT1G58520.6; AT1G58520. [F4IBD7-1]
DR Gramene; AT1G58520.7; AT1G58520.7; AT1G58520. [F4IBD7-1]
DR KEGG; ath:AT1G58520; -.
DR Araport; AT1G58520; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_7_2_1; -.
DR PRO; PR:F4IBD7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IBD7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR032880; Csc1_N.
DR InterPro; IPR027815; PHM7_cyt.
DR InterPro; IPR003864; RSN1_7TM.
DR PANTHER; PTHR13018; PTHR13018; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..746
FT /note="CSC1-like protein RXW8"
FT /id="PRO_0000429808"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 692..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 84848 MW; 96300BD01333937A CRC64;
MEISALLTSA GINISICIVL LSLYSILRKQ PANYCVYFGR RLVCGGARRY DPFWYERFVP
SPSWLVKAWE TSEDELLAAA GLDAVVFLRM VIFSIRIFFI VAVICIAFVL PVNYYGQPMV
HKEIHLESSE VFTIENLKEG SKWLWVHCLA LYIITSAACL LLYFEYSTIA KMRLGHITGC
ASKPSQFTVL IRAIPWSPEQ SYSDTLSKFF TNYYSSSYVS HQMVYHNGII QRLLRDAERM
CQTLKHVSPE INCKPSLRPC TFCGGPTATS SFHILSNEAD SVKGMELGEL TMTTTTTEQE
RSAAFVFFKT RYDALVVSEV LQSSNPMLWV TDLAPEPHDV YWKNLNIPYR QLWIRKIATL
VGAVAFMFVF LIPVTFIQGL TQLVQLSHAF PFLRGILSKN FINQVITGYL PSVILILFFY
AVPPLMMYFS ALEGCISRSI RKKSACIKVL YFTIWNVFFV NILSGSVIRQ LNVFSSVRDI
PAQLARAVPT QAGFFMTYCF TSGWASLACE IMQPMALIWN LVAKVVTKNE DESYETLRFP
YHTEIPRLLL FGLLGFTNSV IAPLILPFLL IYFFLAYLIY KNQILNVYIT KYESGGQYWP
IFHNTTIFSL ILTQIIALGF FGLKLSTVAS GFTIPLILLT LLFSEYCRQR FAPIFNKNPA
QVLIDMDRAD EISGKMEELH KKLHNVYSQI PLHSQKSSSK AECSNPFKKQ ELPDPEKLKP
EEGDAIAKEL WGFQGNESGQ EHDTKS
