CSCLC_ARATH
ID CSCLC_ARATH Reviewed; 703 AA.
AC Q8GUH7; Q39075; Q39126; Q56YE2;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=CSC1-like protein HYP1;
DE AltName: Full=HYPOTHETICAL PROTEIN 1;
GN Name=HYP1; OrderedLocusNames=At3g01100; ORFNames=T4P13.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NUCLEOTIDE SEQUENCE [MRNA] OF
RP 170-703.
RC STRAIN=cv. Columbia;
RX PubMed=7816049; DOI=10.1007/bf00290120;
RA le Guen L., Thomas M., Kreis M.;
RT "Gene density and organization in a small region of the Arabidopsis
RT thaliana genome.";
RL Mol. Gen. Genet. 245:390-396(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=24503647; DOI=10.1038/cr.2014.14;
RA Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S.,
RA Li L.;
RT "DUF221 proteins are a family of osmosensitive calcium-permeable cation
RT channels conserved across eukaryotes.";
RL Cell Res. 24:632-635(2014).
CC -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8GUH7-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF26164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA55187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA56145.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X78422; CAA55187.1; ALT_INIT; mRNA.
DR EMBL; X79707; CAA56145.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC008261; AAF26164.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73610.1; -; Genomic_DNA.
DR EMBL; BT002498; AAO00858.1; -; mRNA.
DR EMBL; BT008419; AAP37778.1; -; mRNA.
DR EMBL; AK221381; BAD94293.1; -; mRNA.
DR PIR; S51583; S51583.
DR RefSeq; NP_186759.2; NM_110975.5. [Q8GUH7-1]
DR AlphaFoldDB; Q8GUH7; -.
DR SMR; Q8GUH7; -.
DR STRING; 3702.AT3G01100.1; -.
DR iPTMnet; Q8GUH7; -.
DR PaxDb; Q8GUH7; -.
DR ProteomicsDB; 220352; -. [Q8GUH7-1]
DR EnsemblPlants; AT3G01100.1; AT3G01100.1; AT3G01100. [Q8GUH7-1]
DR GeneID; 821205; -.
DR Gramene; AT3G01100.1; AT3G01100.1; AT3G01100. [Q8GUH7-1]
DR KEGG; ath:AT3G01100; -.
DR Araport; AT3G01100; -.
DR TAIR; locus:2102117; AT3G01100.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_7_1_1; -.
DR InParanoid; Q8GUH7; -.
DR PhylomeDB; Q8GUH7; -.
DR PRO; PR:Q8GUH7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8GUH7; baseline and differential.
DR Genevisible; Q8GUH7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IDA:TAIR.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR032880; Csc1_N.
DR InterPro; IPR027815; PHM7_cyt.
DR InterPro; IPR003864; RSN1_7TM.
DR PANTHER; PTHR13018; PTHR13018; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Coiled coil; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..703
FT /note="CSC1-like protein HYP1"
FT /id="PRO_0000429810"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 228..300
FT /evidence="ECO:0000255"
FT CONFLICT 273
FT /note="D -> G (in Ref. 5; BAD94293)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="L -> V (in Ref. 1; CAA56145)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 79726 MW; 81E7A2A3A93C3A0C CRC64;
MLLSALLTSV GINLGLCFLF FTLYSILRKQ PSNVTVYGPR LVKKDGKSQQ SNEFNLERLL
PTAGWVKRAL EPTNDEILSN LGLDALVFIR VFVFSIRVFS FASVVGIFIL LPVNYMGTEF
EEFFDLPKKS MDNFSISNVN DGSNKLWIHF CAIYIFTAVV CSLLYYEHKY ILTKRIAHLY
SSKPQPQEFT VLVSGVPLVS GNSISETVEN FFREYHSSSY LSHIVVHRTD KLKVLMNDAE
KLYKKLTRVK SGSISRQKSR WGGFLGMFGN NVDVVDHYQK KLDKLEDDMR LKQSLLAGEE
VPAAFVSFRT RHGAAIATNI QQGIDPTQWL TEAAPEPEDV HWPFFTASFV RRWISNVVVL
VAFVALLILY IVPVVLVQGL ANLHQLETWF PFLKGILNMK IVSQVITGYL PSLIFQLFLL
IVPPIMLLLS SMQGFISHSQ IEKSACIKLL IFTVWNSFFA NVLSGSALYR VNVFLEPKTI
PRVLAAAVPA QASFFVSYVV TSGWTGLSSE ILRLVPLLWS FITKLFGKED DKEFEVPSTP
FCQEIPRILF FGLLGITYFF LSPLILPFLL VYYCLGYIIY RNQLLNVYAA KYETGGKFWP
IVHSYTIFSL VLMHIIAVGL FGLKELPVAS SLTIPLPVLT VLFSIYCQRR FLPNFKSYPT
QCLVNKDKAD EREQNMSEFY SELVVAYRDP ALSASQDSRD ISP
