ID   CSCR_ECOLX              Reviewed;         331 AA.
AC   P62604; P40715;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Sucrose operon repressor;
DE   AltName: Full=Csc operon regulatory protein;
GN   Name=cscR;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EC3132;
RA   Bockmann J.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Repressor for the csc operon. Binds D-fructose as an inducer
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; X81461; CAA57220.1; -; Genomic_DNA.
DR   PIR; S52163; S52163.
DR   RefSeq; WP_001344440.1; NZ_WHZA01000009.1.
DR   AlphaFoldDB; P62604; -.
DR   SMR; P62604; -.
DR   STRING; 585034.ECIAI1_2429; -.
DR   GeneID; 58390317; -.
DR   PATRIC; fig|562.10478.peg.5931; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..331
FT                   /note="Sucrose operon repressor"
FT                   /id="PRO_0000107996"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   331 AA;  36471 MW;  BF9AEA07C10B431F CRC64;
     MASLKDVARL AGVSMMTVSR VMHNAESVRP ATRDRVLQAI QTLNYVPDLS ARKMRAQGRK
     PSTLAVLAQD TATTPFSVDI LLAIEQTASE FGWNSFLINI FSEDDAARAA RQLLAHRPDG
     IIYTTMGLRH ITLPESLYGE NIVLANCVAD DPALPSYIPD DYTAQYESTQ HLLAAGYRQP
     LCFWLPESAL ATGYRRQGFE QAWRDAGRDL AEVKQFHMAT GDDHYTDLAS LLNAHFKSGK
     PDFDVLICGN DRAAFVAYQV LLAKGVRIPQ DVAVMGFDNL VGVGHLFLPP LTTIQLPHDI
     IGREAALHII EGREGGRVTR IPCPLLIRCS T