ID   CSCR_SHIFL              Reviewed;         331 AA.
AC   P62572; P40715;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Sucrose operon repressor;
DE   AltName: Full=Csc operon regulatory protein;
GN   Name=cscR; OrderedLocusNames=SF2431, S2568;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Repressor for the csc operon. Binds D-fructose as an inducer
CC       (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN43942.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP17753.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN43942.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP17753.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_708235.2; NC_004337.2.
DR   RefSeq; WP_001344440.1; NZ_KL503832.1.
DR   AlphaFoldDB; P62572; -.
DR   SMR; P62572; -.
DR   STRING; 198214.SF2431; -.
DR   EnsemblBacteria; AAN43942; AAN43942; SF2431.
DR   EnsemblBacteria; AAP17753; AAP17753; S2568.
DR   GeneID; 1027331; -.
DR   GeneID; 58390317; -.
DR   KEGG; sfl:SF2431; -.
DR   KEGG; sfx:S2568; -.
DR   PATRIC; fig|198214.7.peg.2905; -.
DR   HOGENOM; CLU_037628_6_1_6; -.
DR   OrthoDB; 1796334at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..331
FT                   /note="Sucrose operon repressor"
FT                   /id="PRO_0000107997"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   331 AA;  36471 MW;  BF9AEA07C10B431F CRC64;
     MASLKDVARL AGVSMMTVSR VMHNAESVRP ATRDRVLQAI QTLNYVPDLS ARKMRAQGRK
     PSTLAVLAQD TATTPFSVDI LLAIEQTASE FGWNSFLINI FSEDDAARAA RQLLAHRPDG
     IIYTTMGLRH ITLPESLYGE NIVLANCVAD DPALPSYIPD DYTAQYESTQ HLLAAGYRQP
     LCFWLPESAL ATGYRRQGFE QAWRDAGRDL AEVKQFHMAT GDDHYTDLAS LLNAHFKSGK
     PDFDVLICGN DRAAFVAYQV LLAKGVRIPQ DVAVMGFDNL VGVGHLFLPP LTTIQLPHDI
     IGREAALHII EGREGGRVTR IPCPLLIRCS T