CSDC2_MOUSE
ID CSDC2_MOUSE Reviewed; 154 AA.
AC Q91YQ3; Q3V1F0;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Cold shock domain-containing protein C2;
DE AltName: Full=RNA-binding protein PIPPin;
GN Name=Csdc2; Synonyms=Pippin;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: RNA-binding factor which binds specifically to the very 3'-
CC UTR ends of both histone H1 and H3.3 mRNAs, encompassing the
CC polyadenylation signal. Might play a central role in the negative
CC regulation of histone variant synthesis in the developing brain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=PIPPin-RNA complexes are located to the nucleus. {ECO:0000250}.
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DR EMBL; AK028916; BAC26194.1; -; mRNA.
DR EMBL; AK132493; BAE21201.1; -; mRNA.
DR EMBL; AC102103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016109; AAH16109.1; -; mRNA.
DR CCDS; CCDS27677.1; -.
DR RefSeq; NP_663448.2; NM_145473.3.
DR AlphaFoldDB; Q91YQ3; -.
DR SMR; Q91YQ3; -.
DR BioGRID; 222938; 3.
DR IntAct; Q91YQ3; 2.
DR STRING; 10090.ENSMUSP00000044441; -.
DR iPTMnet; Q91YQ3; -.
DR PhosphoSitePlus; Q91YQ3; -.
DR MaxQB; Q91YQ3; -.
DR PaxDb; Q91YQ3; -.
DR PRIDE; Q91YQ3; -.
DR ProteomicsDB; 277901; -.
DR Antibodypedia; 310; 146 antibodies from 23 providers.
DR DNASU; 105859; -.
DR Ensembl; ENSMUST00000038757; ENSMUSP00000044441; ENSMUSG00000042109.
DR GeneID; 105859; -.
DR KEGG; mmu:105859; -.
DR UCSC; uc007wxs.2; mouse.
DR CTD; 27254; -.
DR MGI; MGI:2146027; Csdc2.
DR VEuPathDB; HostDB:ENSMUSG00000042109; -.
DR eggNOG; KOG3070; Eukaryota.
DR GeneTree; ENSGT00390000000022; -.
DR HOGENOM; CLU_139526_1_0_1; -.
DR InParanoid; Q91YQ3; -.
DR OMA; PVWPIFP; -.
DR OrthoDB; 1560417at2759; -.
DR PhylomeDB; Q91YQ3; -.
DR TreeFam; TF324381; -.
DR BioGRID-ORCS; 105859; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q91YQ3; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q91YQ3; protein.
DR Bgee; ENSMUSG00000042109; Expressed in pontine nuclear group and 259 other tissues.
DR ExpressionAtlas; Q91YQ3; baseline and differential.
DR Genevisible; Q91YQ3; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; ISO:MGI.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0043488; P:regulation of mRNA stability; IBA:GO_Central.
DR CDD; cd04458; CSP_CDS; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR019844; CSD_1.
DR InterPro; IPR002059; CSP_DNA-bd.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR Pfam; PF00313; CSD; 1.
DR SMART; SM00357; CSP; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS00352; CSD_1; 1.
DR PROSITE; PS51857; CSD_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; mRNA processing; Nucleus; Phosphoprotein; Reference proteome;
KW RNA-binding.
FT CHAIN 1..154
FT /note="Cold shock domain-containing protein C2"
FT /id="PRO_0000100352"
FT DOMAIN 69..136
FT /note="CSD"
FT REGION 38..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63430"
FT CONFLICT 7
FT /note="L -> S (in Ref. 3; AAH16109)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 154 AA; 16853 MW; 85D36118B2775930 CRC64;
MTSESTLPPV VPPLHSPKSP VWPTFPFHRE GSRIWERGGG IAPRDLPSPL PTKRTRTYSA
TARASAGPVF KGVCKQFSRS QGHGFITPEN GSEDIFVHVS DIEGEYVPVE GDEVTYKICP
IPPKNQKFQA VEVVLTQLAP HTPHETWSGQ VVGS
