CSE1_SCHPO
ID CSE1_SCHPO Reviewed; 967 AA.
AC O13671; Q9USC9;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1999, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Importin-alpha re-exporter;
DE AltName: Full=Cellular apoptosis susceptibility protein homolog;
GN Name=kap109; ORFNames=pi080, SPBC30B4.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 22-166, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 518-967.
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC re-export from the nucleus to the cytoplasm after import substrates
CC have been released into the nucleoplasm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds with high affinity to importin-alpha only in the
CC presence of RanGTP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus envelope
CC {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA20318.1; -; Genomic_DNA.
DR EMBL; AB027856; BAA87160.1; -; Genomic_DNA.
DR EMBL; AB004539; BAA21462.1; -; Genomic_DNA.
DR PIR; T40171; T40171.
DR RefSeq; NP_595530.1; NM_001021440.2.
DR AlphaFoldDB; O13671; -.
DR SMR; O13671; -.
DR BioGRID; 276947; 3.
DR STRING; 4896.SPBC30B4.05.1; -.
DR iPTMnet; O13671; -.
DR MaxQB; O13671; -.
DR PaxDb; O13671; -.
DR PRIDE; O13671; -.
DR EnsemblFungi; SPBC30B4.05.1; SPBC30B4.05.1:pep; SPBC30B4.05.
DR GeneID; 2540419; -.
DR KEGG; spo:SPBC30B4.05; -.
DR PomBase; SPBC30B4.05; kap109.
DR VEuPathDB; FungiDB:SPBC30B4.05; -.
DR eggNOG; KOG1992; Eukaryota.
DR HOGENOM; CLU_009614_0_0_1; -.
DR InParanoid; O13671; -.
DR OMA; YRYEFKS; -.
DR PhylomeDB; O13671; -.
DR PRO; PR:O13671; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR GO; GO:0031965; C:nuclear membrane; HDA:PomBase.
DR GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR GO; GO:0005525; F:GTP binding; NAS:PomBase.
DR GO; GO:0005049; F:nuclear export signal receptor activity; ISO:PomBase.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006611; P:protein export from nucleus; ISO:PomBase.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR005043; XPO2_C.
DR InterPro; IPR013713; XPO2_central.
DR Pfam; PF03378; CAS_CSE1; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..967
FT /note="Importin-alpha re-exporter"
FT /id="PRO_0000117292"
FT DOMAIN 20..95
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ SEQUENCE 967 AA; 109421 MW; 4ACAB671D4EE3CA5 CRC64;
MDDIPTLLAR TLNPTTSKSA EEALKVWELQ DSSFALKLLN IVAEDTVDIN IKLAASLYFK
NYIKKHWDSE EGASIRISDE VAELIKREII NLMLKSTTII QVQLGEVIGY IANFDFPDRW
DTLLPDLISK LSAVDMNTNI AVLSTAHAIF KRWRPLFRSD ALFLEIKYVL DRFCEPFLAL
FVQTNNLLRN GPQDAESLNS LFQVILLECK LFYDLNCQDI PEFFEDHMSE FMTAFLNYFT
YTNPSLEGDE GETNVLIKVK ASICEIVELY TLRYEEVFTM LYDFVNVTWT LLTTLTPDEK
YDGLVGKAMA FLTSVIRIRK HAEFFQQDQV LQQFIELVVL PNICLRESDE ELFEDDPLEY
VRRDLEGSNS DSRARSAIVL VRGLLDHFDQ KITSVVSTHI NANLQQFSTN PSLEWNKKYV
ALQLFSAIAI KGQSTRLGVT SINLMVDVVA FFENNIKPDL LQPAGVIHPM VLAEDIKYVF
TFRNQLNSQQ LIDIFPTILR FLEMPSFVVY TYAAIALDQL LTVRHNHVHI FTSLLIAPHI
LPALNQLFLI VESASTPQKL AENDYLMKAV MRIIIMSQEA ILPAASLLLQ HLTKITEEVS
KNPSNPKFNH YLFESIGALI RSLSKSGPQT VSQLENALLP VFQNVLIEDV TEFIPYVLQL
LSQLVEASGN EPLPDFVVNL IQPCLSPALW DSKGNIPALV RLLRAMIFRG PQIFISNKFV
EPVLGIFQKL ISSKVNDHFG FDLLDRVFTV FNANILAPYI NHIFFLLLSR LKNSRTERFV
LRCTIFFFFV ASEQTGTCGP DNLIQGVDAV QSGVFGQLMT SIILPQAQKL ALPLDRKISA
LGLLRLLTCD LVLAPDAIYE NLIIPLLTCI LKLFEMPIEQ AQTDADEELF MDEIDADSMS
FQASFSRLAT TGGKRVDPFP QITDLKQYCA TEMNLANRNM GGRLSQIIST HLPGDGQSVL
QSYGYVI