ID   CSEA_STRCO              Reviewed;         225 AA.
AC   Q9ZEP5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Lipoprotein CseA;
DE   Flags: Precursor;
GN   Name=cseA; OrderedLocusNames=SCO3357; ORFNames=SCE94.08;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / M600;
RX   PubMed=10411727; DOI=10.1046/j.1365-2958.1999.01452.x;
RA   Paget M.S.B., Leibowitz E., Buttner M.J.;
RT   "A putative two-component signal transduction system regulates sigE, a
RT   sigma factor required for normal cell wall integrity in Streptomyces
RT   coelicolor A3(2).";
RL   Mol. Microbiol. 33:97-107(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [3]
RP   DETERMINATION OF TRANSLATIONAL START SITE, SUBCELLULAR LOCATION,
RP   CHARACTERIZATION, DIACYLGLYCEROL AT CYS-37, PALMITOYLATION AT CYS-37, AND
RP   MUTAGENESIS OF CYS-37.
RC   STRAIN=A3(2) / M600;
RX   PubMed=17015661; DOI=10.1128/jb.00818-06;
RA   Hutchings M.I., Hong H.J., Leibovitz E., Sutcliffe I.C., Buttner M.J.;
RT   "The sigma(E) cell envelope stress response of Streptomyces coelicolor is
RT   influenced by a novel lipoprotein, CseA.";
RL   J. Bacteriol. 188:7222-7229(2006).
CC   -!- FUNCTION: May be involved in the stabilization of the cell envelope or
CC       may interact with the sensor protein CseC to modulate its activity, in
CC       response to cell envelope stress.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17015661};
CC       Lipid-anchor {ECO:0000269|PubMed:17015661}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA10324.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAB40857.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ131213; CAA10324.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL939116; CAB40857.1; ALT_INIT; Genomic_DNA.
DR   PIR; T36368; T36368.
DR   RefSeq; NP_627565.1; NC_003888.3.
DR   AlphaFoldDB; Q9ZEP5; -.
DR   STRING; 100226.SCO3357; -.
DR   GeneID; 1098794; -.
DR   KEGG; sco:SCO3357; -.
DR   PATRIC; fig|100226.15.peg.3419; -.
DR   eggNOG; ENOG502ZWYH; Bacteria.
DR   HOGENOM; CLU_078792_0_0_11; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..36
FT   CHAIN           37..225
FT                   /note="Lipoprotein CseA"
FT                   /id="PRO_0000314479"
FT   REGION          40..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           37
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000269|PubMed:17015661"
FT   LIPID           37
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000269|PubMed:17015661"
FT   MUTAGEN         37
FT                   /note="C->A: Abolishes attachment to the membrane and
FT                   provokes rapid degradation of mutated protein."
FT                   /evidence="ECO:0000269|PubMed:17015661"
SQ   SEQUENCE   225 AA;  23435 MW;  AE78AE8D57AEE330 CRC64;
     MRGLTDGRTP RGTRRTTQAA STAVAVFVAL GVSLAGCGTG GTGARDEGPA HADAVGGAGS
     ASPAPAAKAS PSKAPDRVDA VRLVKADPKV SPEVKRELKP CVADEYPIDV SYGKVTDGSA
     DDVVVNVLTC GDAVGVGSYV YREEDGAYQN VFKAEEPPVY AEIDRGDLVV TKQVYDKGDP
     VSSPSGENVI TYRWASDRFT EEYRTHNDYS KAAGNAPTPA PEPDS