ID   CSEB_STRCO              Reviewed;         234 AA.
AC   Q9ZEP4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 137.
DE   RecName: Full=Transcriptional regulatory protein CseB;
GN   Name=cseB; OrderedLocusNames=SCO3358; ORFNames=SCE94.09;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN TRANSCRIPTIONAL
RP   ACTIVATION OF SIGMA E.
RC   STRAIN=A3(2) / M600;
RX   PubMed=10411727; DOI=10.1046/j.1365-2958.1999.01452.x;
RA   Paget M.S.B., Leibowitz E., Buttner M.J.;
RT   "A putative two-component signal transduction system regulates sigE, a
RT   sigma factor required for normal cell wall integrity in Streptomyces
RT   coelicolor A3(2).";
RL   Mol. Microbiol. 33:97-107(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system CseB/CseC
CC       involved in the stability of the cell envelope. CseB activates
CC       transcription of RNA polymerase sigma-E factor, in response to changes
CC       in the cell envelope. {ECO:0000269|PubMed:10411727}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by CseC. {ECO:0000305}.
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DR   EMBL; AJ131213; CAA10325.1; -; Genomic_DNA.
DR   EMBL; AL939116; CAB40858.1; -; Genomic_DNA.
DR   PIR; T36369; T36369.
DR   RefSeq; NP_627566.1; NC_003888.3.
DR   RefSeq; WP_003975477.1; NZ_VNID01000023.1.
DR   AlphaFoldDB; Q9ZEP4; -.
DR   SMR; Q9ZEP4; -.
DR   STRING; 100226.SCO3358; -.
DR   GeneID; 1098795; -.
DR   KEGG; sco:SCO3358; -.
DR   PATRIC; fig|100226.15.peg.3420; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_11; -.
DR   InParanoid; Q9ZEP4; -.
DR   OMA; WGGDTRV; -.
DR   PhylomeDB; Q9ZEP4; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..234
FT                   /note="Transcriptional regulatory protein CseB"
FT                   /id="PRO_0000314481"
FT   DOMAIN          6..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        140..234
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   234 AA;  25382 MW;  2D714CFF98FAAC4F CRC64;
     MADQTHVLFV EDDDVIREAT QLALERDGFA VTAMPDGLSG LESFRADRPD IALLDVMLPG
     LDGVSLCRRI RDESTVPVIM LSARADSIDV VLGLEAGADD YVTKPFDGAV LVARIRAVLR
     RFGHAGGGDR TEGAGAAETG GVLTFGDLEV DTDGMEVRRA GRPVGLTPTE MRLLLEFSSA
     PGTVLSRDKL LERVWDYGWG GDTRVVDVHV QRLRTKIGQD RIETVRGFGY KLKA