CSEN4_MOUSE
ID CSEN4_MOUSE Reviewed; 89 AA.
AC P0C092;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Calsenilin isoform 4;
GN Name=Kcnip3; Synonyms=Csen, Dream, Kchip3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [GENOMIC DNA],
RP AND TISSUE SPECIFICITY.
RX PubMed=11161465; DOI=10.1006/mcne.2000.0913;
RA Spreafico F., Barski J.J., Farina C., Meyer M.;
RT "Mouse DREAM/calsenilin/KChIP3: gene structure, coding potential and
RT expression.";
RL Mol. Cell. Neurosci. 17:1-16(2001).
CC -!- FUNCTION: Unknown for isoform 4. Csen is involved in calcium-dependent
CC transcriptional repression, regulation of potassium channels, and
CC perhaps in processing of PSEN2 and apoptosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=4; Synonyms=DREAM T+;
CC IsoId=P0C092-1; Sequence=Displayed;
CC Name=1; Synonyms=Calsenilin/KChIP3 T+;
CC IsoId=Q9QXT8-1; Sequence=External;
CC Name=2; Synonyms=Calsenilin/KChIP3 T-;
CC IsoId=Q9QXT8-2; Sequence=External;
CC Name=3; Synonyms=DREAM T-;
CC IsoId=Q9QXT8-3; Sequence=External;
CC -!- TISSUE SPECIFICITY: Isoform 1 or isoform 4 (T+ forms) are expressed at
CC equal levels with isoform 2 or isoform 3 (T- forms) in brain.
CC {ECO:0000269|PubMed:11161465}.
CC -!- MISCELLANEOUS: [Isoform 4]: Lacks EF-hand domains.
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DR EMBL; AF287737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0C092; -.
DR PRIDE; P0C092; -.
DR ProteomicsDB; 285342; -. [P0C092-1]
DR MGI; MGI:1929258; Kcnip3.
DR ChiTaRS; Kcnip3; mouse.
DR Proteomes; UP000000589; Unplaced.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0043679; C:axon terminus; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0032993; C:protein-DNA complex; ISO:MGI.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IPI:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0015459; F:potassium channel regulator activity; ISO:MGI.
DR GO; GO:0008022; F:protein C-terminus binding; IPI:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR GO; GO:0048266; P:behavioral response to pain; IMP:MGI.
DR GO; GO:0006886; P:intracellular protein transport; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; TAS:MGI.
DR GO; GO:0006813; P:potassium ion transport; TAS:MGI.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; IDA:MGI.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0048265; P:response to pain; IMP:MGI.
DR GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..89
FT /note="Calsenilin isoform 4"
FT /id="PRO_0000073816"
FT REGION 27..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 89 AA; 9471 MW; 02229EE1CDC6CC09 CRC64;
MRQLPAGPSS LACSGCKAGR LVTVPFSSRD AEDQGSREGI GWQPPGRSWA HTTEQEGKHQ
VAKATVHPPG PDALLLNQVD PVQCCPTRL
