CSF1_YEAST
ID CSF1_YEAST Reviewed; 2958 AA.
AC Q12150; D6VY87;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein CSF1;
DE AltName: Full=Cold sensitive for fermentation protein 1;
GN Name=CSF1; OrderedLocusNames=YLR087C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=10781556; DOI=10.1128/jb.182.10.2865-2868.2000;
RA Tokai M., Kawasaki H., Kikuchi Y., Ouchi K.;
RT "Cloning and characterization of the CSF1 gene of Saccharomyces cerevisiae,
RT which is required for nutrient uptake at low temperature.";
RL J. Bacteriol. 182:2865-2868(2000).
CC -!- FUNCTION: Required for the glucose and other nutrients uptake at low
CC temperature. {ECO:0000269|PubMed:10781556}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CSF1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U53880; AAB67591.1; -; Genomic_DNA.
DR EMBL; Z73259; CAA97647.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09403.1; -; Genomic_DNA.
DR PIR; S64921; S64921.
DR RefSeq; NP_013188.1; NM_001181974.1.
DR BioGRID; 31360; 595.
DR IntAct; Q12150; 2.
DR MINT; Q12150; -.
DR STRING; 4932.YLR087C; -.
DR TCDB; 8.A.6.1.1; the auxiliary nutrient transporter (ant) family.
DR iPTMnet; Q12150; -.
DR MaxQB; Q12150; -.
DR PaxDb; Q12150; -.
DR PRIDE; Q12150; -.
DR EnsemblFungi; YLR087C_mRNA; YLR087C; YLR087C.
DR GeneID; 850776; -.
DR KEGG; sce:YLR087C; -.
DR SGD; S000004077; CSF1.
DR VEuPathDB; FungiDB:YLR087C; -.
DR eggNOG; KOG3596; Eukaryota.
DR HOGENOM; CLU_000126_1_0_1; -.
DR InParanoid; Q12150; -.
DR OMA; YTWHYYR; -.
DR BioCyc; YEAST:G3O-32238-MON; -.
DR PRO; PR:Q12150; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q12150; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0006113; P:fermentation; IMP:SGD.
DR GO; GO:0051604; P:protein maturation; IMP:SGD.
DR InterPro; IPR029636; Csf1.
DR PANTHER; PTHR32085; PTHR32085; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..2958
FT /note="Protein CSF1"
FT /id="PRO_0000228143"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..2958
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 813..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 478
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 530
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 816
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 821
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 839
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 892
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1785
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1921
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2280
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2520
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2578
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2719
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2869
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 2958 AA; 338258 MW; 66464C61CF608156 CRC64;
MEAISQLRGV PLTHQKDFSW VFLVDWILTV VVCLTMIFYM GRIYAYLVSF ILEWLLWKRA
KIKINVETLR VSLLGGRIHF KNLSVIHKDY TISVLEGSLT WKYWLLNCRK AELIENNKSS
SGKKAKLPCK ISVECEGLEI FIYNRTVAYD NVINLLSKDE RDKFEKYLNE HSFPEPFSDG
SSADKLDEDL SESAYTTNSD ASIVNDRDYQ ETDIGKHPKL LMFLPIELKF SRGSLLLGNK
FTPSVMILSY ESGKGIIDVL PPKERLDLYR NKTQMEFKNF EISIKQNIGY DDAIGLKFKI
DRGKVSKLWK TFVRVFQIVT KPVVPKKTKK SAGTSDDNFY HKWKGLSLYK ASAGDAKASD
LDDVEFDLTN HEYAKFTSIL KCPKVTIAYD VDVPGVVPHG AHPTIPDIDG PDVGNNGAPP
DFALDVQIHG GSICYGPWAQ RQVSHLQRVL SPVVSRTAKP IKKLPPGSRR IYTLFRMNIS
IMEDTTWRIP TRESSKDPEF LKHYKETNEE YRPFGWMDLR FCKDTYANFN ISVCPTVQGF
QNNFHVHFLE TEIRSSVNHD ILLKSKVFDI DGDIGYPLGW NSKAIWIINM KSEQLEAFLL
REHITLVADT LSDFSAGDPT PYELFRPFVY KVNWEMEGYS IYLNVNDHNI VNNPLDFNEN
CYLSLHGDKL SIDVTVPRES ILGTYTDMSY EISTPMFRMM LNTPPWNTLN EFMKHKEVGR
AYDFTIKGSY LLYSELDIDN VDTLVIECNS KSTVLHCYGF VMRYLTNVKM NYFGEFFNFV
TSEEYTGVLG AREVGDVTTK SSVADLASTV DSGYQNSSLK NESEDKGPMK RSDLKRTTNE
TDIWFTFSVW DGALILPETI YSFDPCIALH FAELVVDFRS CNYYMDIMAV LNGTSIKRHV
SKQINEVFDF IRRNNGADEQ EHGLLSDLTI HGHRMYGLPP TEPTYFCQWD INLGDLCIDS
DIEFIKGFFN SFYKIGFGYN DLENILLYDT ETINDMTSLT VHVEKIRIGL KDPVMKSQSV
ISAESILFTL IDFENEKYSQ RIDVKIPKLT ISLNCVMGDG VDTSFLKFET KLRFTNFEQY
KDIDKKRSEQ RRYITIHDSP YHRCPFLLPL FYQDSDTYQN LYGAIAPSSS IPTLPLPTLP
DTIDYIIEDI VGEYATLLET TNPFKNIFAE TPSTMEPSRA SFSEDDNDEE ADPSSFKPVA
FTEDRNHERD NYVVDVSYIL LDVDPLLFIF AKSLLEQLYS ENMVQVLDDI EIGIVKRLSN
LQEGITSISN IDIHIAYLNL IWQETGEEGF ELYLDRIDYQ MSEKSLEKNR TNKLLEVAAL
AKVKTVRVTV NQKKNPDLSE DRPPALSLGI EGFEVWSSTE DRQVNSLNLT SSDITIDESQ
MEWLFEYCSD QGNLIQEVCT SFNSIQNTRS NSKTELISKL TAASEYYQIS HDPYVITKPA
FIMRLSKGHV RENRSWKIIT RLRHILTYLP DDWQSNIDEV LKEKKYTSAK DAKNIFMSVF
STWRNWEFSD VARSYIYGKL FTAENEKHKQ NLIKKLLKCT MGSFYLTVYG EGYEVEHNFV
VADANLVVDL TPPVTSLPSN REETIEITGR VGSVKGKFSD RLLKLQDLIP LIAAVGEDDK
SDPKKELSKQ FKMNTVLLVD KSELQLVMDQ TKLMSRTVGG RVSLLWENLK DSTSQAGSLV
IFSQKSEVWL KHTSVILGEA QLRDFSVLAT TEAWSHKPTI LINNQCADLH FRAMSSTEQL
VTAITEIRES LMMIKERIKF KPKSKKKSQF VDQKINTVLS CYFSNVSSEV MPLSPFYIRH
EAKQLDIYFN KFGSNEILLS IWDTDFFMTS HQTKEQYLRF SFGDIEIKGG ISREGYSLIN
VDISISMIKL TFSEPRRIVN SFLQDEKLAS QGINLLYSLK PLFFSSNLPK KEKQAPSIMI
NWTLDTSITY FGVLVPVAST YFVFELHMLL LSLTNTNNGM LPEETKVTGQ FSIENILFLI
KERSLPIGLS KLLDFSIKVS TLQRTVDTEQ SFQVESSHFR VCLSPDSLLR LMWGAHKLLD
LSHYYSRRHA PNIWNTKMFT GKSDKSKEMP INFRSIHILS YKFCIGWIFQ YGAGSNPGLM
LGYNRLFSAY EKDFGKFTVV DAFFSVANGN TSSTFFSEGN EKDKYNRSFL PNMQISYWFK
RCGELKDWFF RFHGEALDVN FVPSFMDVIE STLQSMRAFQ ELKKNILDVS ESLRAENDNS
YASTSVESAS SSLAPFLDNI RSVNSNFKYD GGVFRVYTYE DIETKSEPSF EIKSPVVTIN
CTYKHDEDKV KPHKFRTLIT VDPTHNTLYA GCAPLLMEFS ESLQKMIKKH STDEKPNFTK
PSSQNVDYKR LLDQFDVAVK LTSAKQQLSL SCEPKAKVQA DVGFESFLFS MATNEFDSEQ
PLEFSLTLEH TKASIKHIFS REVSTSFEVG FMDLTLLFTH PDVISMYGTG LVSDLSVFFN
VKQLQNLYLF LDIWRFSSIL HTRPVQRTVN KEIEMSSLTS TNYADAGTEI PWCFTLIFTN
VSGDVDLGPS LGMISLRTQR TWLATDHYNE KRQLLHAFTD GISLTSEGRL SGLFEVANAS
WLSEVKWPPE KSKNTHPLVS TSLNIDDIAV KAAFDYHMFL IGTISNIHFH LHNEKDAKGV
LPDLLQVSFS SDEIILSSTA LVVANILDIY NTIVRMRQDN KISYMETLRD SNPGESRQPI
LYKDILRSLK LLRTDLSVNI SSSKVQISPI SLFDVEVLVI RIDKVSIRSE THSGKKLKTD
LQLQVLDVSA ALSTSKEELD EEVGASIAID DYMHYASKIV GGTIIDIPKL AVHMTTLQEE
KTNNLEYLFA CSFSDKISVR WNLGPVDFIK EMWTTHVKAL AVRRSQVANI SFGQTEEELE
ESIKKEEAAS KFNYIALEEP QIEVPQIRDL GDATPPMEWF GVNRKKFPKF THQTAVIPVQ
KLVYLAEKQY VKILDDTH
